Evidence map›Paper›PMID 21490757›Full record

ArticleJournal of drug delivery2011

Recent applications of liposomes in ophthalmic drug delivery.

Gyan P Mishra, Mahuya Bagui, Viral Tamboli, Ashim K Mitra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Review
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  9. Role of miRNA in adult ocular tumorigenesis.Frontiers in molecular biosciences · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gyan P MishraDivision of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108-2718, USA.
Mahuya Bagui
Viral Tamboli
Ashim K Mitra

Funding

Ocular Disposition of Antimicrobial AgentsR01EY009171 · NEI · UNIVERSITY OF MISSOURI KANSAS CITY · PI MITRA, ASHIM K. · 1992 to 2010
$3.0M
Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular EdR01EY010659 · NEI · UNIVERSITY OF MISSOURI KANSAS CITY · PI MITRA, ASHIM K. · 1996 to 2010
$2.5M
NEI NIH HHS R01 EY009171NEI NIH HHS R01 EY010659
6 · The paper itself

Abstract

Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on improving the corneal adhesion and permeation by incorporating various bioadhesive and penetration enhancing polymers. In the case of posterior segment disorders improvement in intravitreal half life and targeted drug delivery to the retina is achieved by liposomes. In this paper we have attempted to summarize the applications of liposomes in the field of ophthalmic drug delivery by citing numerous investigators over the last decade.

Identifiers

PMID21490757
PMCPMC3066533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.