ArticleInternational journal of molecular imaging2011
Molecular image analysis: quantitative description and classification of the nuclear lamina in human mesenchymal stem cells.
Article in International journal of molecular imaging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology.Nature communications · 2017Article
- Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification.ISRN molecular biology · 2013Review
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Authors and funding
6 authors.
Funding
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Abstract
The nuclear lamina is an intermediate filament network that provides a structural framework for the cell nucleus. Changes in lamina structure are found during changes in cell fate such as cell division or cell death and are associated with human diseases. An unbiased method that quantifies changes in lamina shape can provide information on cells undergoing changes in cellular functions. We have developed an image processing methodology that finds and quantifies the 3D structure of the nuclear lamina. We show that measurements on such images can be used for cell classification and provide information concerning protein spatial localization in this structure. To demonstrate the efficacy of this method, we compared the lamina of unmanipulated human mesenchymal stem cells (hMSCs) at passage 4 to cells activated for apoptosis. A statistically significant classification was found between the two populations.
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Registered trials
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