ArticleFrontiers in neuroscience2011
Enhanced integration of newborn neurons after neonatal insults.
Article in Frontiers in neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Neuroinflammatory mechanisms of post-traumatic epilepsy.Journal of neuroinflammation · 2020Review
- Apolipoprotein E regulates the maturation of injury-induced adult-born hippocampal neurons following traumatic brain injury.PloS one · 2020Article
- Converging early responses to brain injury pave the road to epileptogenesis.Journal of neuroscience research · 2019Review
- Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss.Neurobiology of aging · 2017Article
- Article
- Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury(1,2,3).eNeuro · 2015Article
- Using sex differences in the developing brain to identify nodes of influence for seizure susceptibility and epileptogenesis.Neurobiology of disease · 2014Review
- Age, plasticity, and homeostasis in childhood brain disorders.Neuroscience and biobehavioral reviews · 2013Review
- GABA depolarization is required for experience-dependent synapse unsilencing in adult-born neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neurobehavioral and neurodevelopmental effects of pesticide exposures.Neurotoxicology · 2012Article
- A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Dynamic functions of GABA signaling during granule cell maturation.Frontiers in neural circuits · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The production and integration of adult-generated neurons in the dentate gyrus is dramatically perturbed by a variety of pathological insults, including repetitive seizures and hypoxia/ischemia. Less is known about how insults affect early postnatal neurogenesis, during the developmental period when the majority of dentate neurons are produced. Here we tested how single episodes of hypoxia or chemically induced seizure activity in postnatal day 10 mice alter granule cell production and integration. Although neither insult was sufficient to alter the number of newborn neurons nor the population of proliferating cells, both treatments increased the dendritic complexity of newborn granule cells that were born around the time of the insult. Surprisingly, only the dendritic enhancement caused by hypoxia was associated with increased synaptic integration. These results suggest that alterations in dendritic integration can be dissociated from altered neural production and that integration appears to have a lower threshold for perturbation. Furthermore, newborn neurons in adult mice that experienced neonatal hypoxia had reduced dendritic length while having no alterations in number. Together these results suggest that single insults during the neonatal period can have both long- and short-term consequences for neuronal maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.