Trial reportJournal of human hypertension2012
Regional grey matter shrinks in hypertensive individuals despite successful lowering of blood pressure.
Trial report in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies.Neuroscience and biobehavioral reviews · 2014Pooled it
- Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.Journal of the American Heart Association · 2025Article
- Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging.Neuromolecular medicine · 2024Article
- Article
- Abnormal changes in neuropsychological function, brain structure and cerebral perfusion in patients with unruptured intracranial aneurysms.Frontiers in neurology · 2024Article
- Association of brain morphology and phenotypic profile in patients with unruptured intracranial aneurysm.Frontiers in aging neuroscience · 2023Article
- Genetic Insights into the Risk of Metabolic Syndrome and Its Components on Dementia: A Mendelian Randomization.Journal of Alzheimer's disease : JAD · 2023Article
- The relationship between isolated hypertension with brain volumes in UK Biobank.Brain and behavior · 2022Article
- Clonidine and Brain Mitochondrial Energy Metabolism: Pharmacodynamic Insights Beyond Receptorial Effects.Neurochemical research · 2022Article
- Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank.Journal of Alzheimer's disease : JAD · 2021Article
- Right hippocampal volume mediation of subjective memory complaints differs by hypertension status in healthy aging.Neurobiology of aging · 2020Article
- Frontostriatal Brain Activation Is Associated With the Longitudinal Progression of Cardiometabolic Risk.Psychosomatic medicine · 2020Article
- Cumulative Blood Pressure Exposure, Basal Ganglia, and Thalamic Morphology in Midlife.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Analyzing brain structural differences associated with categories of blood pressure in adults using empirical kernel mapping-based kernel ELM.Biomedical engineering online · 2019Article
- Characteristic changes in the default mode network in hypertensive patients with cognitive impairment.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Increased stressor-evoked cardiovascular reactivity is associated with reduced amygdala and hippocampus volume.Psychophysiology · 2019Article
- A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review.American journal of physiology. Heart and circulatory physiology · 2018Review
- Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction.Frontiers in neurology · 2018Article
- High salt induced hypertension leads to cognitive defect.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The aim of the study was to determine whether the reduction in brain grey matter volume associated with hypertension persisted or was remediated among hypertensive patients newly treated over the course of a year. A total of 41 hypertensive patients were assessed over the course of a 1-year successful anti-hypertensive treatment. Brain areas identified previously in cross-sectional studies differing in volume between hypertensive and normotensive individuals were examined with a semi-automated measurement technique (automated labelling pathway). Volumes of grey matter regions were computed at baseline after a year of treatment and compared with archival data from normotensive individuals. Reductions in regional grey matter volume over the follow-up period were observed despite successful treatment of blood pressure (BP). The comparison group of older, but normotensive, individuals showed no significant changes over a year in the regions tested in the treated hypertensive group. These novel results suggest that essential hypertension is associated with regional grey matter shrinkage, and successful reduction of BP may not completely counter that trend.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.