ArticleThe Journal of experimental biology2011
Insulin-like peptide genes in honey bee fat body respond differently to manipulation of social behavioral physiology.
Article in The Journal of experimental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 111 citations in OpenAlex.
- Diet Quality Shapes Metabolic and Immune Transcriptional Responses of Honey Bees Under Acute Heat Stress.Insects · 2026Article
- AI-enhanced marker-assisted selection concept for the multifunctional honey bee (Hymenoptera: Apidea) protein Vitellogenin (Vg).Journal of economic entomology · 2025Article
- Impact of carbohydrate sources on the longevity and physiological traits of the European honey bee workers.Scientific reports · 2025Article
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- Remodeling of Cellular Respiration and Insulin Signaling Are Part of a Shared Stress Response in Divergent Bee Species.Insects · 2025Article
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- Comparative Study of the Effect of Pollen Substitute Diets on Honey Bees during Early Spring.Insects · 2024Article
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- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Carbohydrate nutrition associated with health of overwintering honey bees.Journal of insect science (Online) · 2023Article
- Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis.G3 (Bethesda, Md.) · 2023Article
- Honey bee functional genomics using symbiont-mediated RNAi.Nature protocols · 2023Review
- Decoupling the effects of nutrition, age, and behavioral caste on honey bee physiology, immunity, and colony health.Frontiers in physiology · 2023Article
- Antibiotics Alter the Expression of Genes Related to Behavioral Development in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
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- The trophocytes and oenocytes of worker and queen honey bees (Apis mellifera) exhibit distinct age-associated transcriptome profiles.GeroScience · 2021Article
- Antibiotic Treatment Decrease the Fitness of Honeybee (Insects · 2021Article
- High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Nutrient sensitive insulin-like peptides (ILPs) have profound effects on invertebrate metabolism, nutrient storage, fertility and aging. Many insects transcribe ILPs in specialized neurosecretory cells at changing levels correlated with life history. However, the major site of insect metabolism and nutrient storage is not the brain, but rather the fat body, where functions of ILP expression are rarely studied and poorly understood. Fat body is analogous to mammalian liver and adipose tissue, with nutrient stores that often correlate with behavior. We used the honey bee (Apis mellifera), an insect with complex behavior, to test whether ILP genes in fat body respond to experimentally induced changes of behavioral physiology. Honey bee fat body influences endocrine state and behavior by secreting the yolk protein precursor vitellogenin (Vg), which suppresses lipophilic juvenile hormone and social foraging behavior. In a two-factorial experiment, we used RNA interference (RNAi)-mediated vg gene knockdown and amino acid nutrient enrichment of hemolymph (blood) to perturb this regulatory module. We document factor-specific changes in fat body ilp1 and ilp2 mRNA, the bee's ILP-encoding genes, and confirm that our protocol affects social behavior. We show that ilp1 and ilp2 are regulated independently and differently and diverge in their specific expression-localization between fat body oenocyte and trophocyte cells. Insect ilp functions may be better understood by broadening research to account for expression in fat body and not only brain.
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