ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 58 citations in OpenAlex.
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- An advanced approach for the electrical responses of discrete fractional-order biophysical neural network models and their dynamical responses.Scientific reports · 2023Article
- Cellular rules underlying psychedelic control of prefrontal pyramidal neurons.bioRxiv : the preprint server for biology · 2023Article
- Diverse electrical responses in a network of fractional-order conductance-based excitable Morris-Lecar systems.Scientific reports · 2023Article
- Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Classification of bursting patterns: A tale of two ducks.PLoS computational biology · 2022Review
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
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- Chronic defects in intraspinal mechanisms of spike encoding by spinal motoneurons following chemotherapy.Experimental neurology · 2020Article
- Central Role of Subthreshold Currents in Myotonia.Annals of neurology · 2020Review
- Emergence of Mixed Mode Oscillations in Random Networks of Diverse Excitable Neurons: The Role of Neighbors and Electrical Coupling.Frontiers in computational neuroscience · 2020Article
- Scaling of Motor Output, From Mouse to Humans.Physiology (Bethesda, Md.) · 2019Review
- The Subprimary Range of Firing Is Present in Both Cat and Mouse Spinal Motoneurons and Its Relationship to Force Development Is Similar for the Two Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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- Increasing motor neuron excitability to treat weakness in sepsis.Annals of neurology · 2017Article
- PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.Journal of neurophysiology · 2017Article
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explain the mechanism that elicits the mixed mode oscillations (MMOs) and the subprimary firing range that we recently discovered in mouse spinal motoneurons. In this firing regime, high-frequency subthreshold oscillations appear a few millivolts below the spike voltage threshold and precede the firing of a full blown spike. By combining intracellular recordings in vivo (including dynamic clamp experiments) in mouse spinal motoneurons and modeling, we show that the subthreshold oscillations are due to the spike currents and that MMOs appear each time the membrane is in a low excitability state. Slow kinetic processes largely contribute to this low excitability. The clockwise hysteresis in the I-F relationship, frequently observed in mouse motoneurons, is mainly due to a substantial slow inactivation of the sodium current. As a consequence, less sodium current is available for spiking. This explains why a large subprimary range with numerous oscillations is present in motoneurons displaying a clockwise hysteresis. In motoneurons whose I-F curve exhibits a counterclockwise hysteresis, it is likely that the slow inactivation operates on a shorter time scale and is substantially reduced by the de-inactivating effect of the afterhyperpolarization (AHP) current, thus resulting in a more excitable state. This accounts for the short subprimary firing range with only a few MMOs seen in these motoneurons. Our study reveals a new role for the AHP current that sets the membrane excitability level by counteracting the slow inactivation of the sodium current and allows or precludes the appearance of MMOs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.