ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Overcoming Barriers to Axonal Regeneration in Spinal Cord Injury: Mechanistic Insights and Therapeutic Frontiers.CNS neuroscience & therapeutics · 2026Review
- Neuromechanical Strategies for Obstacle Negotiation during Overground Locomotion following Incomplete Spinal Cord Injury in Adult Cats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Modulation of the gait pattern during split-belt locomotion after lateral spinal cord hemisection in adult cats.Journal of neurophysiology · 2022Article
- Chronic muscle recordings reveal recovery of forelimb function in spinal injured female rats after cortical epidural stimulation combined with rehabilitation and chondroitinase ABC.Journal of neuroscience research · 2022Article
- Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review).Molecular medicine reports · 2021Review
- Proteoglycan-depleted regions of annular injury promote nerve ingrowth in a rabbit disc degeneration model.Open medicine (Warsaw, Poland) · 2021Article
- Treadmill-Based Gait Kinematics in the Yucatan Mini Pig.Journal of neurotrauma · 2020Article
- Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury.Journal of neuroscience research · 2020Article
- Anatomical Plasticity of Rostrally Terminating Axons as a Possible Bridging Substrate across a Spinal Injury.Journal of neurotrauma · 2020Article
- A three dimensional multiplane kinematic model for bilateral hind limb gait analysis in cats.PloS one · 2018Article
- Immunization with neural derived peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury.BMC neuroscience · 2017Article
- Article
- Enhancing Fluorogold-based neural tract tracing.Journal of neuroscience methods · 2016Article
- Guiding migration of transplanted glial progenitor cells in the injured spinal cord.Scientific reports · 2016Article
- Mdivi-1 Inhibits Astrocyte Activation and Astroglial Scar Formation and Enhances Axonal Regeneration after Spinal Cord Injury in Rats.Frontiers in cellular neuroscience · 2016Article
- Molecular mechanisms of scar-sourced axon growth inhibitors.Brain research · 2015Review
- Histamine promotes locomotion recovery after spinal cord hemisection via inhibiting astrocytic scar formation.CNS neuroscience & therapeutics · 2015Article
- Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.Experimental neurology · 2015Article
- Article
- Mammalian target of rapamycin's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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3 authors.
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Abstract
A number of studies have shown that chondroitinase ABC (Ch'ase ABC) digestion of inhibitory chondroitin sulfate glycosaminoglycans significantly enhances axonal growth and recovery in rodents following spinal cord injury (SCI). Further, our group has shown improved recovery following SCI in the larger cat model. The purpose of the current study was to determine whether intraspinal delivery of Ch'ase ABC, following T10 hemisections in adult cats, enhances adaptive movement features during a skilled locomotor task and/or promotes plasticity of spinal and supraspinal circuitry. Here, we show that Ch'ase ABC enhanced crossing of a peg walkway post-SCI and significantly improved ipsilateral hindlimb trajectories and integration into a functional forelimb-hindlimb coordination pattern. Recovery of these complex movements was associated with significant increases in neurofilament immunoreactivity immediately below the SCI in the ipsilateral white (p = 0.033) and contralateral gray matter (p = 0.003). Further, the rubrospinal tract is critical in the normal cat during skilled movements that require accurate paw placements and trajectories like those seen during peg walkway crossing. Rubrospinal connections were assessed following Fluoro-Gold injections, caudal to the hemisection. Significantly more retrogradely labeled right (axotomized) red nucleus (RN) neurons were seen in Ch'ase ABC-treated (23%) compared with control-treated cats (8%; p = 0.032) indicating that a larger number of RN neurons in Ch'ase ABC-treated cats had axons below the lesion level. Thus, following SCI, Ch'ase ABC may facilitate axonal growth at the spinal level, enhance adaptive features of locomotion, and affect plasticity of rubrospinal circuitry known to support adaptive behaviors in the normal cat.
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