ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Transcription factor Foxd1 is required for the specification of the temporal retina in mammals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 64 citations in OpenAlex.
- Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development.Development (Cambridge, England) · 2026Article
- Decoding transcriptional identity during neuron-astroglia cell fate driven by RAR-specific agonists.NAR molecular medicine · 2025Article
- EphA4 Mediates EphrinB1-Dependent Adhesion in Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Cep120 is essential for kidney stromal progenitor cell growth and differentiation.EMBO reports · 2024Article
- The Prognostic Significance of FOXD1 Expression in Head and Neck Squamous Cell Carcinoma.Journal of personalized medicine · 2023Article
- Foxd1-dependent induction of a temporal retinal character is required for visual function.Development (Cambridge, England) · 2022Article
- Transcriptional Control of Axon Guidance at Midline Structures.Frontiers in cell and developmental biology · 2022Review
- DNA-based eyelid trait prediction in Chinese Han population.International journal of legal medicine · 2021Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Neurogenesis and Specification of Retinal Ganglion Cells.International journal of molecular sciences · 2020Review
- The hedgehog pathway and ocular developmental anomalies.Human genetics · 2019Review
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- Molecular guidance cues in the development of visual pathway.Protein & cell · 2018Review
- Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The multisystemic functions of FOXD1 in development and disease.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes.Developmental biology · 2018Article
- Mouse Metanephric Mesenchymal Cell-Derived Angioblasts Undergo Vasculogenesis in Three-Dimensional Culture.The American journal of pathology · 2018Article
- Identification of an Enhancer Critical for theMolecules and cells · 2017Article
- FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells.Cancer research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of the visual system is different in birds and mammals. In both, retinal axons project topographically to the visual targets in the brain; but whereas in birds visual fibers from the entire retina decussate at the optic chiasm, in mammals, a number of axons from the temporal retina diverge at the midline to project ipsilaterally. Gain-of-function experiments in chick raised the hypothesis that the transcription factor Foxd1 specifies retinal temporal identity. However, it remains unknown whether Foxd1 is necessary for this function. In mammals, the crucial role of Foxd1 in the patterning of the optic chiasm region has complicated the interpretation of its cell-autonomous function in the retina. Furthermore, target molecules identified for Foxd1 are different in chicks and mice, leading to question the function of Foxd1 in mammals. Here we show that in the mouse, Foxd1 imprints temporal features in the retina such as axonal ipsilaterality and rostral targeting in collicular areas and that EphA6 is a Foxd1 downstream effector that sends temporal axons to the rostral colliculus. In addition, our data support a model in which the desensitization of EphA6 by ephrinA5 in cis is not necessary for the proper functioning of EphA6. Overall, these results indicate that Foxd1 functions as a conserved determinant of temporal identity but reveal that the downstream effectors, and likely their mechanisms of action, are different in mammals and birds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.