ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adult neuroplasticity employs developmental mechanisms.Frontiers in systems neuroscience · 2022Pooled it
- Time Window of the Critical Period for Neuroplasticity in S1, V1, and A1 Sensory Areas of Small Rodents: A Systematic Review.Frontiers in neuroanatomy · 2022Pooled it
- Age-Dependent Auditory Plasticity: Critical Periods in Subcortical and Cortical Encoding.Journal of audiology & otology · 2026Review
- TNF-α Deficiency Reduces Parvalbumin Neuron Density, Impairs Homeostatic Plasticity, Disrupts Synaptic Excitation-Inhibition Balance, and Prevents Critical Period Closure in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex.Nature communications · 2025Article
- Learning to hear again with alternating cochlear frequency allocations.Scientific reports · 2025Article
- Pairing with Enriched Sound Exposure Restores Auditory Processing Degraded by an Antidepressant.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Developmental Exposure to Bisphenol a Degrades Auditory Cortical Processing in Rats.Neuroscience bulletin · 2022Article
- N-methyl-D-aspartate receptor antagonism impairs sensory gating in the auditory cortex in response to speech stimuli.Psychopharmacology · 2022Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modifying the Adult Rat Tonotopic Map with Sound Exposure Produces Frequency Discrimination Deficits That Are Recovered with Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Disinhibition of Human Primary Somatosensory Cortex After Median Nerve Transection and Reinnervation.Frontiers in human neuroscience · 2020Article
- Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex.Frontiers in cellular neuroscience · 2020Article
- The rat animal model for noise-induced hearing loss.The Journal of the Acoustical Society of America · 2019Review
- Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity.Neuroscience and biobehavioral reviews · 2019Review
- Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction.Journal of bioenergetics and biomembranes · 2019Review
- PET Imaging of Perceptual Learning-Induced Changes in the Aged Rodent Cholinergic System.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Since its first description >40 years ago, the neurological "critical period" has been predominantly described as an early, plastic postnatal brain development stage that rather abruptly advances to an aplastic or less plastic "adult" stage. Here, we show that chronic exposure of juvenile or adult rats to moderate-level acoustic noise results in a broad reversal of maturational changes that mark the infant-to-adult progression in the primary auditory cortex. In time, noise exposure reinstates critical period plasticity. Cortical changes resulting from noise exposure are again reversed to reestablish a physically and functionally normal adult cortex, by returning animals to natural acoustic environments. These studies show that at least some of neurological changes believed to mark the transition from the infantile to the mature (adult) stage are, by their nature, reversible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.