ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
DNA endoreplication in the brain neurons during body growth of an adult slug.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Transgenesis enables mapping of segmental ganglia in the leech Helobdella austinensis.The Journal of experimental biology · 2024Article
- Cell Cycle Re-entry in the Nervous System: From Polyploidy to Neurodegeneration.Frontiers in cell and developmental biology · 2021Review
- Polyploidy in the adulteLife · 2020Article
- Cell-Size Control.Cold Spring Harbor perspectives in biology · 2016Review
- The effects of acute cold exposure on morphology and gene expression in the heart of neonatal chicks.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells.Cell cycle (Georgetown, Tex.) · 2015Article
- The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth.Development (Cambridge, England) · 2014Article
- Insulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in Drosophila.PLoS genetics · 2013Article
- Report on the 12th symposium on invertebrate neurobiology held 31 August-4 September 2011 at the Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary.Invertebrate neuroscience : IN · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endoreplication is DNA synthesis without cell division. Giant neurons observed in the brains of mollusks are thought to be generated as a result of DNA endoreplication. It has been hypothesized that neuronal size becomes larger in parallel with an increase in body size and that DNA endoreplication is involved in this process to meet the increasing demand for macromolecules in neurons. There is, however, no experimental evidence for this hypothesis to date. In the present study, we investigated the following quantitatively: (1) the size of the brain and each ganglion, (2) the size of identified neurons, (3) the total number of neurons undergoing DNA endoreplication, (4) the total number of the neurons containing a cardioexcitatory peptide, and (5) the gene expression level per neuron, using terrestrial slugs whose body growth was regulated through the amount of food supplied in the laboratory. The body growth was accompanied by increases in the sizes of both neurons and ganglia and triggered more frequent DNA endoreplication events in each ganglion of the growth-promoted slugs, without increasing the total number of neurons. Increase in the neuronal size also involved the increase in the amount of transcripts expressed in a single neuron. This is the first quantitative evidence showing that the DNA endoreplication, neuronal size, and gene expression are increased concomitantly with body growth in adult mollusks.
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