ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed, 91 citations in OpenAlex.
- Mapping memory at scale: systems-level insights with translational and transdiagnostic relevance to fear-related disorders.Frontiers in behavioral neuroscience · 2026Review
- Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics.Neuroscience bulletin · 2025Review
- The role of the claustrum in the acquisition, consolidation and reconsolidation of memories in mice.Scientific reports · 2024Article
- Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment.International journal of molecular sciences · 2023Review
- Targeting CaN/NFAT in Alzheimer's brain degeneration.Frontiers in immunology · 2023Review
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Short-term memory reactivation of a weak CS-US association promotes long-term memory persistence in conditioned odor aversion.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Intra-prefrontal cyclosporine potentiates ketamine-induced fear extinction in rats.Experimental brain research · 2021Article
- Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between.Frontiers in behavioral neuroscience · 2020Review
- The lateral neocortex is critical for contextual fear memory reconsolidation.Scientific reports · 2019Article
- Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction.Frontiers in molecular neuroscience · 2019Article
- Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice.Molecular neurobiology · 2018Article
- Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats.Scientific reports · 2018Article
- A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Synaptically Localized Transcriptional Regulators in Memory Formation.Neuroscience · 2018Review
- Astrocyte Activation and the Calcineurin/NFAT Pathway in Cerebrovascular Disease.Frontiers in aging neuroscience · 2018Review
- Enhancement of extinction memory by pharmacological and behavioral interventions targeted to its reactivation.Scientific reports · 2017Article
- On the transition from reconsolidation to extinction of contextual fear memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes fear memory reconsolidation, whereas a prolonged reexposure induces memory extinction. The regulation of hippocampal gene expression plays a key role in contextual memory consolidation and reconsolidation. However, the mechanisms that determine whether memory will reconsolidate or extinguish are not known. Here, we demonstrate opposing roles for two evolutionarily related transcription factors in the mouse hippocampus. We found that nuclear factor-κB (NF-κB) is required for fear memory reconsolidation. Conversely, calcineurin phosphatase inhibited NF-κB and induced nuclear factor of activated T-cells (NFAT) nuclear translocation in the transition between reconsolidation and extinction. Accordingly, the hippocampal inhibition of both calcineurin and NFAT independently impaired memory extinction, whereas inhibition of NF-κB enhanced memory extinction. These findings represent the first insight into the molecular mechanisms that determine memory reprocessing after retrieval, supporting a transcriptional switch that directs memory toward reconsolidation or extinction. The precise molecular characterization of postretrieval processes has potential importance to the development of therapeutic strategies for fear memory disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.