ArticleMolecular biology of the cell2011
A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Temperature duringbioRxiv : the preprint server for biology · 2026Article
- Molecular propensity and stress tolerance of dehydrins from desert plants.Scientific reports · 2025Article
- Distinct roles of phytochromes A and B inmBio · 2025Article
- Article
- Compatible solutes determine the heat resistance of conidia.Fungal biology and biotechnology · 2023Article
- Article
- Plant dehydrins and dehydrin-like proteins: characterization and participation in abiotic stress response.Frontiers in plant science · 2023Review
- Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022Review
- Characterization of theInternational journal of molecular sciences · 2021Article
- Genetic Interactions BetweenFrontiers in fungal biology · 2021Article
- The Putative APSES Transcription Factor RgdA Governs Growth, Development, Toxigenesis, and Virulence in Aspergillus fumigatus.mSphere · 2020Article
- Molecular Mechanisms of Conidial Germination inMicrobiology and molecular biology reviews : MMBR · 2020Review
- Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station.Fungal genetics and biology : FG & B · 2019Article
- Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions.Frontiers in microbiology · 2019Article
- Responses to Hydric Stress in the Seed-Borne Necrotrophic FungusFrontiers in microbiology · 2019Article
- Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal PathogenmSphere · 2018Article
- Expression profile analysis reveals that Aspergillus fumigatus but not Aspergillus niger makes type II epithelial lung cells less immunological alert.BMC genomics · 2018Article
- Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion.BMC genomics · 2018Article
- The Aspergillus fumigatus SchAMolecular microbiology · 2016Article
- Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison.Frontiers in cellular and infection microbiology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a search for genes controlling conidial dormancy in Aspergillus fumigatus, two dehydrin-like genes, DprA and DprB, were identified. The deduced proteins had repeated stretches of 23 amino acids that contained a conserved dehydrin-like protein (DPR) motif. Disrupted DprAΔ mutants were hypersensitive to oxidative stress and to phagocytic killing, whereas DprBΔ mutants were impaired in osmotic and pH stress responses. However, no effect was observed on their pathogenicity in our experimental models of invasive aspergillosis. Molecular dissection of the signaling pathways acting upstream showed that expression of DprA was dependent on the stress-activated kinase SakA and the cyclic AMP-protein kinase A (cAMP-PKA) pathways, which activate the bZIP transcription factor AtfA, while expression of DprB was dependent on the SakA mitogen-activated protein kinase (MAPK) pathway, and the zinc finger transcription factor PacC. Fluorescent protein fusions showed that both proteins were associated with peroxisomes and the cytosol. Accordingly, DprA and DprB were important for peroxisome function. Our findings reveal a novel family of stress-protective proteins in A. fumigatus and, potentially, in filamentous ascomycetes.
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