ArticleAmerican journal of physiology. Renal physiology2011
Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025Article
- Comparison of the Nitric Oxide Synthase Interactomes and S-Nitroso-Proteomes: Furthering the Case for Enzymatic S-Nitrosylation.Antioxidants & redox signaling · 2023Article
- Role for ovarian hormones in purinoceptor-dependent natriuresis.Biology of sex differences · 2020Article
- Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance.Neuro-oncology · 2018Article
- Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice.Journal of the American Society of Nephrology : JASN · 2017Article
- Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production.Oncology letters · 2017Article
- Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3.Journal of hypertension · 2017Article
- Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner.American journal of physiology. Renal physiology · 2016Article
- High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- In vivo organ specific drug delivery with implantable peristaltic pumps.Scientific reports · 2016Article
- Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.American journal of physiology. Renal physiology · 2015Article
- Nitric oxide and carbon monoxide antagonize TGF-β through ligand-independent internalization of TβR1/ALK5.American journal of physiology. Renal physiology · 2014Article
- Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3.American journal of physiology. Heart and circulatory physiology · 2014Article
- FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.PloS one · 2014Article
- Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD.American journal of physiology. Renal physiology · 2013Article
- Hypertension: what's sex got to do with it?Physiology (Bethesda, Md.) · 2013Review
- Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.Clinical and experimental pharmacology & physiology · 2013Article
- Nitric oxide and the A and B of endothelin of sodium homeostasis.Current opinion in nephrology and hypertension · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that nitric oxide synthase (NOS) isoforms may be regulated by dynamin (DNM) in the inner medullary collecting duct (IMCD). The aims of this study were to determine which DNM isoforms (DNM1, DNM2, DNM3) are expressed in renal IMCDs, whether DNM interacts with NOS, whether a high-salt diet alters the interaction of DNM and NOS, and whether DNM activates NO production. DNM2 and DNM3 are highly expressed in the rat IMCD, while DNM1 is localized outside of the IMCD. We found that DNM1 interacts with NOS1α, NOS1β, and NOS3 in the inner medulla of male Sprague-Dawley rats on a 0.4% salt diet. DNM2 interacts with NOS1α, while DNM3 interacts with both NOS1α and NOS1β. DNM2 and DNM3 do not interact with NOS3 in the rat inner medulla. We did not observe any change in the DNM/NOS interactions with rats on a 4% salt diet after 7 days. Furthermore, NOS1α interacts with DNM2 in mIMCD3 and COS7 cells transfected with NOS1α and DNM2-GFP constructs and the NOS1 reductase domain is necessary for the interaction. Finally, COS7 cells expressing NOS1α or NOS1α/DNM2-GFP had significantly higher nitrite production compared with DNM2-GFP only. Nitrite production was blocked by the DNM inhibitor dynasore or the dominant negative DNM2K44A. Ionomycin stimulation further increased nitrite production in the NOS1α/DNM2-GFP cells compared with NOS1α only. In conclusion, DNM and NOS1 interact in the rat renal IMCD and this interaction leads to increased NO production, which may influence NO production in the renal medulla.
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