ArticleCancer prevention research (Philadelphia, Pa.)2011
Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice.
Article in Cancer prevention research (Philadelphia, Pa.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Glutathione peroxidase 4 suppresses manganese-dependent oxidative stress to reduce colorectal tumorigenesis.Research square · 2024Article
- Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity.Membranes · 2021Review
- Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk.Digestive diseases and sciences · 2020Review
- Omega-3 fatty acids, membrane remodeling and cancer prevention.Molecular aspects of medicine · 2018Review
- The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines.Biochemical pharmacology · 2018Review
- Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA.The British journal of nutrition · 2018Article
- Emerging role of chemoprotective agents in the dynamic shaping of plasma membrane organization.Biochimica et biophysica acta. Biomembranes · 2017Review
- Dietary fat and fiber interactively modulate apoptosis and mitochondrial bioenergetic profiles in mouse colon in a site-specific manner.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Article
- The Interaction between Dietary Fiber and Fat and Risk of Colorectal Cancer in the Women's Health Initiative.Nutrients · 2016Article
- G-protein-coupled receptors mediate ω-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway.Oncotarget · 2016Article
- Effects of different dietary n-6/n-3 polyunsaturated fatty acid ratios on boar reproduction.Lipids in health and disease · 2016Article
- Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt.Biochimica et biophysica acta · 2016Article
- A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells.Carcinogenesis · 2014Article
- High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria.PloS one · 2014Article
- Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial.American journal of epidemiology · 2013Article
- Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids.Prostaglandins, leukotrienes, and essential fatty acids · 2013Review
- Alteration of colonic stem cell gene signatures during the regenerative response to injury.Biochimica et biophysica acta · 2012Article
- n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization.Molecular aspects of medicine · 2012Review
- Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse.PloS one · 2011Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
An alteration of mitochondrial function can result in disruption of redox homeostasis and is associated with abnormal cancer cell growth. Manganese superoxide dismutase (SOD2) and glutathione peroxidase 4 (Gpx4) are two of the most important antioxidant defense enzymes that protect cells against oxidative stress. We had previously shown that n-3 polyunsaturated fatty acids (PUFA) promote colonocyte apoptosis, a marker of colon cancer risk, in part by enhancing phospholipid oxidation. To elucidate the mechanisms regulating oxidative stress-induced apoptosis in vivo, we fed heterozygous SOD2(Het), Gpx4(Het), and transgenic Gpx4(Tg) mice diets containing either 15% corn oil by weight (CO, enriched in n-6 PUFA) or 3.5% CO + 11.5% fish oil (FO, enriched in n-3 PUFA) for 4 weeks. Our data showed that (i) genetic predeposition to oxidative stress facilitates apoptosis in the mouse colon (Gpx4(Het) > SOD2(Het) > Wt > Gpx4(Tg)), (ii) dietary n-3 PUFA have an additive effect on the induction of apoptosis in Gpx4(Het) and SOD2(Het) mice; and (iii) dietary n-3 PUFA reverse the phenotype in oxidatively protected Gpx4(Tg) mice by elevating apoptosis to a level observed in wild-type (Wt; control) animals. Complimentary experiments examining colonic mitochondrial bioenergetic profiles indicate that FO-fed mice exhibit a significantly (P < 0.05) increased respiration-induced proton leak relative to control CO treatment. This finding was consistent with a loss of membrane potential in response to chronic oxidative stress and supports the contention that n-3 PUFA alter mitochondrial metabolic activity, thereby enhancing apoptosis and reducing colon cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.