ArticleDevelopment (Cambridge, England)2011
Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development.Nature communications · 2024Article
- Finishing the egg.Genetics · 2024Article
- A maternal dorsoventral prepattern revealed by an asymmetric distribution of ventralizing molecules before fertilization inFrontiers in cell and developmental biology · 2024Article
- Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo.Stem cell reports · 2023Article
- Article
- Epithelial morphogenesis in theFrontiers in cell and developmental biology · 2022Article
- Polarity Events in theFrontiers in cell and developmental biology · 2022Review
- Identification and functional analysis of five genes that encode distinct isoforms of protein phosphatase 1 in Nilaparvata lugens.Scientific reports · 2020Article
- Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration.eLife · 2020Article
- Actomyosin contractility modulates Wnt signaling through adherens junction stability.Molecular biology of the cell · 2019Article
- A Gene Expression Screen inG3 (Bethesda, Md.) · 2019Article
- Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling inDevelopment (Cambridge, England) · 2018Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
- Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis.Nature communications · 2016Article
- Integrins regulate epithelial cell differentiation by modulating Notch activity.Journal of cell science · 2014Article
- Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis.The Journal of cell biology · 2014Article
- Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.PloS one · 2013Article
- A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation.G3 (Bethesda, Md.) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila body axes are established in the oocyte during oogenesis. Oocyte polarization is initiated by Gurken, which signals from the germline through the epidermal growth factor receptor (Egfr) to the posterior follicle cells (PFCs). In response the PFCs generate an unidentified polarizing signal that regulates oocyte polarity. We have identified a loss-of-function mutation of flapwing, which encodes the catalytic subunit of protein phosphatase 1β (PP1β) that disrupts oocyte polarization. We show that PP1β, by regulating myosin activity, controls the generation of the polarizing signal. Excessive myosin activity in the PFCs causes oocyte mispolarization and defective Notch signaling and endocytosis in the PFCs. The integrated activation of JAK/STAT and Egfr signaling results in the sensitivity of PFCs to defective Notch. Interestingly, our results also demonstrate a role of PP1β in generating the polarizing signal independently of Notch, indicating a direct involvement of somatic myosin activity in axis formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.