ArticleProceedings. Biological sciences2011
Exclusion rules, bottlenecks and the evolution of stochastic phenotype switching.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
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- Efflux-linked accelerated evolution of antibiotic resistance at a population edge.Molecular cell · 2022Article
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- Aggregative cycles evolve as a solution to conflicts in social investment.PLoS computational biology · 2021Article
- Adaptation is influenced by the complexity of environmental change during evolution in a dynamic environment.PLoS genetics · 2021Article
- Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise.PLoS computational biology · 2019Article
- Repeated Phenotypic Evolution by Different Genetic Routes in Pseudomonas fluorescens SBW25.Molecular biology and evolution · 2019Article
- Ribosome Provisioning Activates a Bistable Switch Coupled to Fast Exit from Stationary Phase.Molecular biology and evolution · 2019Article
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- PhasomeIt: an 'omics' approach to cataloguing the potential breadth of phase variation in the genus Campylobacter.Microbial genomics · 2018Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Programmed cell death can increase the efficacy of microbial bet -hedging.Scientific reports · 2018Article
- Nascent life cycles and the emergence of higher-level individuality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The impact of bottlenecks on microbial survival, adaptation, and phenotypic switching in host-pathogen interactions.Evolution; international journal of organic evolution · 2017Article
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- Coarse-grained analysis of stochastically simulated cell populations with a positive feedback genetic network architecture.Journal of mathematical biology · 2015Article
- Bistability in a metabolic network underpins the de novo evolution of colony switching in Pseudomonas fluorescens.PLoS biology · 2015Article
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2 authors.
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Abstract
Stochastic phenotype switching--often considered a bet hedging or risk-reducing strategy--can enhance the probability of survival in fluctuating environments. A recent experiment provided direct evidence for an adaptive origin by showing the de novo evolution of switching in bacterial populations propagated under a selective regime that captured essential features of the host immune response. The regime involved strong frequency-dependent selection realized via dual imposition of an exclusion rule and population bottleneck. Applied at the point of transfer between environments, the phenotype common in the current environment was assigned a fitness of zero and was thus excluded from participating in the next round (the exclusion rule). In addition, also at the point of transfer, and so as to found the next bout of selection, a single phenotypically distinct type was selected at random from among the survivors (the bottleneck). Motivated by this experiment, we develop a mathematical model to explore the broader significance of key features of the selective regime. Through a combination of analytical and numerical results, we show that exclusion rules and population bottlenecks act in tandem as potent selective agents for stochastic phenotype switching, such that even when initially rare, and when switching engenders a cost in Malthusian fitness, organisms with the capacity to switch can invade non-switching populations and replace non-switching types. Simulations demonstrate the robustness of our findings to alterations in switching rate, fidelity of exclusion, bottleneck size, duration of environmental state and growth rate. We also demonstrate the relevance of our model to a range of biological scenarios such as bacterial persistence and the evolution of sex.
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