ArticleSchizophrenia research2011
Paternal age and psychiatric disorders: findings from a Dutch population registry.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- A assessment of the effects of parental age on the development of autism in children: a systematic review and a meta-analysis.BMC psychology · 2024Pooled it
- Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021Pooled it
- Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies.Schizophrenia bulletin · 2021Pooled it
- Pooled it
- Trial
- Effect of parental age on treatment response in adolescents with schizophrenia.Schizophrenia research · 2013Trial
- Increased paternal age and the influence on burden of genomic copy number variation in the general population.Human genetics · 2013Trial
- Age-related changes in lncRNA expression in sperm.Translational andrology and urology · 2025Article
- Review
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Paternal age and specific neurological soft signs as reliable and valid neurobiological markers for the diagnosis of patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- A multifactorial model for the etiology of neuropsychiatric disorders: the role of advanced paternal age.Pediatric research · 2022Review
- Analysis of Trend and Associated Factors of Neuropsychological Development of Infants and Toddlers Based on Longitudinal Data.Children (Basel, Switzerland) · 2021Article
- Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.Schizophrenia research · 2021Review
- Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study.Molecular autism · 2020Article
- Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.Biomedical reports · 2020Article
- Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.Journal of assisted reproduction and genetics · 2019Article
- Non-Genetic Factors in Schizophrenia.Current psychiatry reports · 2019Review
- Predictors of Internalizing Behaviors in Ukrainian Children.Family relations · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWe measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population.
methodsIn total, 14231 patients and 56924 matched controls were collected and analyzed for an association with paternal age by logistic regression.
resultsASD is significantly associated with increased paternal age: Older fathers >40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers <20 years of age. SCZ has significant associations for fathers aged >35 years (OR=1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD.
conclusionsThe effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.