Evidence map›Paper›PMID 21489647›Full record

ReviewTrends in biotechnology2011

Cancer theranostics: the rise of targeted magnetic nanoparticles.

Adam J Cole, Victor C Yang, Allan E David

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam J ColeDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109-1065, USA.
Victor C Yang
Allan E David

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
PTD-Mediated Protein or Drug Delivery for Cancer TherapyR01CA114612 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, VICTOR C · 2005 to 2015
$2.5M
MION for Synchronized MRI and Drug Therapy of Brain TumorR01NS066945 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, VICTOR C · 2009 to 2010
$770k
NCI NIH HHS R01 CA114612NIGMS NIH HHS GM007767NIGMS NIH HHS T32 GM007767NINDS NIH HHS R01 NS066945
6 · The paper itself

Abstract

Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of MNPs as potential "theranostics". Here we review both the key technical principles of MNPs and ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.

Indexed as

Biomedical ResearchDrug CarriersHumansMagnetite NanoparticlesNeoplasmsDrug CarriersMagnetite Nanoparticles

Identifiers

PMID21489647
PMCPMC3210200

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.