ReviewCritical care (London, England)2011
Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.
Review in Critical care (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- CVVHD results in longer filter life than pre-filter CVVH: Results of a quasi-randomized clinical trial.PloS one · 2023Trial
- Trial
- Low-intensity versus medium-intensity continuous renal replacement therapy for critically ill patients (LIMIT) trial: Protocol summary and statistical analysis plan of a randomised clinical trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Article
- Article
- Article
- The association between continuous renal replacement therapy as treatment for sepsis-associated acute kidney injury and trend of lactate trajectory as risk factor of 28-day mortality in intensive care units.BMC emergency medicine · 2022Article
- The effect of continuous venovenous hemodiafiltration on amino acid delivery, clearance, and removal in children.Pediatric nephrology (Berlin, Germany) · 2022Observational
- Dose of Continuous Renal Replacement Therapy in Critically Ill Patients: A Bona Fide Quality Indicator.Nephron · 2021Review
- Renal replacement therapy in intensive care units in KwaZulu-Natal Province, South Africa.The Southern African journal of critical care : the official journal of the Critical Care Society · 2021Article
- Renal replacement therapy: a practical update.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2019Review
- Process based quality improvement using a continuous renal replacement therapy dashboard.BMC nephrology · 2019Article
- Treatment dose and the elimination rates of electrolytes, vitamins, and trace elements during continuous veno-venous hemodialysis (CVVHD).International urology and nephrology · 2018Article
- Antibiotic Dosing in Sustained Low-Efficiency Dialysis in Critically Ill Patients.Canadian journal of kidney health and disease · 2018Review
- Application of continuous renal replacement therapy for acute kidney injury in elderly patients.International journal of clinical and experimental medicine · 2015Article
- Challenges and pitfalls when implementing renal replacement therapy in the ICU.Critical care (London, England) · 2015Article
- The lower limit of intensity to control uremia during continuous renal replacement therapy.Critical care (London, England) · 2014Article
- Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy.Critical care (London, England) · 2014Review
- Effectiveness of pharmacist dosing adjustment for critically ill patients receiving continuous renal replacement therapy: a comparative study.Therapeutics and clinical risk management · 2014Article
- Current therapeutic strategies for acute kidney injury.Clinical and experimental nephrology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous renal replacement therapy (CRRT) is the preferred treatment for acute kidney injury in intensive care units (ICUs) throughout much of the world. Despite the widespread use of CRRT, controversy and center-specific practice variation in the clinical application of CRRT continue. In particular, whereas two single-center studies have suggested survival benefit from delivery of higher-intensity CRRT to patients with acute kidney injury in the ICU, other studies have been inconsistent in their results. Now, however, two large multi-center randomized controlled trials - the Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network (ATN) study and the Randomized Evaluation of Normal versus Augmented Level (RENAL) Replacement Therapy Study - have provided level 1 evidence that effluent flow rates above 25 mL/kg per hour do not improve outcomes in patients in the ICU. In this review, we discuss the concept of dose of CRRT, its relationship with clinical outcomes, and what target optimal dose of CRRT should be pursued in light of the high-quality evidence now available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.