ArticleMolecular brain2011
A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel.
Article in Molecular brain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Configuration of electrical synapses filters sensory information to drive behavioral choices.Cell · 2025Article
- A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.EMBO reports · 2023Article
- Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels.PLoS genetics · 2022Article
- NaJournal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Gap junctions: historical discoveries and new findings in theBiology open · 2020Review
- Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.Nature communications · 2020Article
- Article
- Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal inGenetics · 2018Article
- The NCA-1 and NCA-2 Ion Channels Function Downstream of GGenetics · 2017Article
- Article
- Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.PLoS genetics · 2016Article
- Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans.Molecular biology of the cell · 2016Article
- Mechanosensitive unpaired innexin channels in C. elegans touch neurons.American journal of physiology. Cell physiology · 2014Article
- The sodium leak channel, NALCN, in health and disease.Frontiers in cellular neuroscience · 2014Review
- NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels.PloS one · 2013Article
- Article
- NALCN: a regulator of pacemaker activity.Molecular neurobiology · 2012Review
- Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans.Current opinion in neurobiology · 2012Review
- A uniquely adaptable pore is consistent with NALCN being an ion sensor.Channels (Austin, Tex.)Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions mediate the electrical coupling and intercellular communication between neighboring cells. Some gap junction proteins, namely connexins and pannexins in vertebrates, and innexins in invertebrates, may also function as hemichannels. A conserved NCA/Dmα1U/NALCN family cation leak channel regulates the excitability and activity of vertebrate and invertebrate neurons. In the present study, we describe a genetic and functional interaction between the innexin UNC-7 and the cation leak channel NCA in Caenorhabditis elegans neurons. While the loss of the neuronal NCA channel function leads to a reduced evoked postsynaptic current at neuromuscular junctions, a simultaneous loss of the UNC-7 function restores the evoked response. The expression of UNC-7 in neurons reverts the effect of the unc-7 mutation; moreover, the expression of UNC-7 mutant proteins that are predicted to be unable to form gap junctions also reverts this effect, suggesting that UNC-7 innexin regulates neuronal activity, in part, through gap junction-independent functions. We propose that, in addition to gap junction-mediated functions, UNC-7 innexin may also form hemichannels to regulate C. elegans' neuronal activity cooperatively with the NCA family leak channels.
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