ArticleBMC research notes2011
Comparison between nasopharyngeal swab and nasal wash, using culture and PCR, in the detection of potential respiratory pathogens.
Article in BMC research notes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage.PLoS pathogens · 2012Trial
- Nasal Microbiota Associated with the Lung Radiomic Features in Asthma.International journal of general medicine · 2026Article
- 3D printed fluidic swab for COVID-19 testing with improved diagnostic yield and user comfort.Nano convergence · 2023Article
- Paroxysmal Atrial Fibrillation with Rapid Ventricular Response Following COVID-19 Nasopharyngeal Swab: A Case Report.Reports (MDPI) · 2023Article
- Nasopharyngeal Swabs vs. Nasal Aspirates for Respiratory Virus Detection: A Systematic Review.Pathogens (Basel, Switzerland) · 2021Review
- The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.Scientific reports · 2021Article
- Performing nasopharyngeal swabs-Guidelines based on an anatomical study.Clinical anatomy (New York, N.Y.) · 2021Article
- The microbiome of the nasopharynx.Journal of medical microbiology · 2021Review
- Article
- Improved Influenza Diagnostics through Thermal Contrast Amplification.Diagnostics (Basel, Switzerland) · 2021Article
- Bronchoalveolar lavage-based COVID-19 testing in patients with cancer.Hematology/oncology and stem cell therapy · 2021Article
- Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic.American journal of respiratory and critical care medicine · 2021Article
- Rapid Fabrication of Sterile Medical Nasopharyngeal Swabs by Stereolithography for Widespread Testing in a Pandemic.Advanced engineering materials · 2020Article
- Minimally Invasive Nasal Sampling in Children Offers Accurate Pneumococcal Colonization Detection.The Pediatric infectious disease journal · 2019Article
- Development and application of multiplex PCR assays for detection of virus-induced respiratory disease complex in dogs.The Journal of veterinary medical science · 2017Article
- Pneumococcal Colonization Rates in Patients Admitted to a United Kingdom Hospital with Lower Respiratory Tract Infection: a Prospective Case-Control Study.Journal of clinical microbiology · 2016Article
- Density and duration of experimental human pneumococcal carriage.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Article
- Impact of experimental human pneumococcal carriage on nasopharyngeal bacterial densities in healthy adults.PloS one · 2014Article
- Article
- Serotype-independent pneumococcal vaccines.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNasopharyngeal carriage of potential pathogens is important as it is both the major source of transmission and the prerequisite of invasive disease. New methods for detecting carriage could improve comfort, accuracy and laboratory utility. The aims of this study were to compare the sensitivities of a nasopharyngeal swab (NPS) and a nasal wash (NW) in detecting potential respiratory pathogens in healthy adults using microbiological culture and PCR.
resultsHealthy volunteers attended for nasal washing and brushing of the posterior nasopharynx. Conventional and real-time PCR were used to detect pneumococcus and meningococcus. Statistical differences between the two nasal sampling methods were determined using a nonparametric Mann-Whitney U test; differences between culture and PCR methods were determined using the McNemar test.Nasal washing was more comfortable for volunteers than swabbing (n = 24). In detection by culture, the NW was significantly more likely to detect pathogens than the NPS (p < 0.00001). Overall, there was a low carriage rate of pathogens in this sample; no significant difference was seen in the detection of bacteria between culture and PCR methods.
conclusionsNasal washing and PCR may provide effective alternatives to nasopharyngeal swabbing and classical microbiology, respectively.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.