ArticleDiagnostic pathology2011
How to measure diagnosis-associated information in virtual slides.
Article in Diagnostic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Accuracy of whole slide image based image analysis is adversely affected by preanalytical factors such as stained tissue slide and paraffin block age.Journal of pathology informatics · 2022Article
- Enhancing the Value of Histopathological Assessment of Allograft Biopsy Monitoring.Transplantation · 2019Review
- Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Reproducibility and Prognostic Potential of Ki-67 Proliferation Index when Comparing Digital-Image Analysis with Standard Semi-Quantitative Evaluation in Breast Cancer.Pathology oncology research : POR · 2018Article
- Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast.Diagnostic pathology · 2014Observational
- Quantification of myocardial fibrosis by digital image analysis and interactive stereology.Diagnostic pathology · 2014Article
- A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue.Breast cancer research : BCR · 2014Article
- Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis.Expert review of molecular diagnostics · 2013Review
- CognitionMaster: an object-based image analysis framework.Diagnostic pathology · 2013Article
- The history of pathology informatics: A global perspective.Journal of pathology informatics · 2013Article
- Determining similarity in histological images using graph-theoretic description and matching methods for content-based image retrieval in medical diagnostics.Diagnostic pathology · 2012Article
- Molecular characteristics and chromatin texture features in acute promyelocytic leukemia.Diagnostic pathology · 2012Article
- Introduction of virtual microscopy in routine surgical pathology--a hypothesis and personal view from Europe.Diagnostic pathology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of diagnosis-associated information in histological slides is often spatial dependent. A reliable selection of the slide areas containing the most significant information to deriving the associated diagnosis is a major task in virtual microscopy. Three different algorithms can be used to select the appropriate fields of view: 1) Object dependent segmentation combined with graph theory; 2) time series associated texture analysis; and 3) geometrical statistics based upon geometrical primitives. These methods can be applied by sliding technique (i.e., field of view selection with fixed frames), and by cluster analysis. The implementation of these methods requires a standardization of images in terms of vignette correction and gray value distribution as well as determination of appropriate magnification (method 1 only). A principle component analysis of the color space can significantly reduce the necessary computation time. Method 3 is based upon gray value dependent segmentation followed by graph theory application using the construction of (associated) minimum spanning tree and Voronoi's neighbourhood condition. The three methods have been applied on large sets of histological images comprising different organs (colon, lung, pleura, stomach, thyroid) and different magnifications, The trials resulted in a reproducible and correct selection of fields of view in all three methods. The different algorithms can be combined to a basic technique of field of view selection, and a general theory of "image information" can be derived. The advantages and constraints of the applied methods will be discussed.
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