ArticleThe European journal of neuroscience2011
Characterization of orderly spatiotemporal patterns of clock gene activation in mammalian suprachiasmatic nucleus.
Article in The European journal of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 76 citations in OpenAlex.
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- Suprachiasmatic nucleus-wide estimation of oscillatory temporal dynamics.PLoS computational biology · 2025Article
- On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Bmal1 integrates circadian function and temperature sensing in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reduced Plasticity in Coupling Strength in the Aging SCN Clock as Revealed by Kuramoto Modeling.Journal of biological rhythms · 2023Article
- Phenotyping of light-activated neurons in the mouse SCN based on the expression of FOS and EGR1.Frontiers in physiology · 2023Article
- Single cell model for re-entrainment to a shifted light cycle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Timed daily exercise remodels circadian rhythms in mice.Communications biology · 2021Article
- Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice.PLoS computational biology · 2021Article
- Seasonality and light phase-resetting in the mammalian circadian rhythm.Scientific reports · 2020Article
- Uncovering functional signature in neural systems via random matrix theory.PLoS computational biology · 2019Article
- The Biological Clock in Gray Mouse Lemur: Adaptive, Evolutionary and Aging Considerations in an Emerging Non-human Primate Model.Frontiers in physiology · 2019Review
- CLOCKΔ19 mutation modifies the manner of synchrony among oscillation neurons in the suprachiasmatic nucleus.Scientific reports · 2018Article
- Moran's I quantifies spatio-temporal pattern formation in neural imaging data.Bioinformatics (Oxford, England) · 2017Article
- Differential localization of PER1 and PER2 in the brain master circadian clock.The European journal of neuroscience · 2017Article
- Resynchronization Dynamics Reveal that the Ventral Entrains the Dorsal Suprachiasmatic Nucleus.Journal of biological rhythms · 2017Article
- Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus.Scientific reports · 2016Article
- Timing by rhythms: Daily clocks and developmental rulers.Development, growth & differentiation · 2016Review
- Evidence for Weakened Intercellular Coupling in the Mammalian Circadian Clock under Long Photoperiod.PloS one · 2016Article
- Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC2-signaling deficient mice.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Because we can observe oscillation within individual cells and in the tissue as a whole, the suprachiasmatic nucleus (SCN) presents a unique system in the mammalian brain for the analysis of individual cells and the networks of which they are a part. While dispersed cells of the SCN sustain circadian oscillations in isolation, they are unstable oscillators that require network interactions for robust cycling. Using cluster analysis to assess bioluminescence in acute brain slices from PERIOD2::Luciferase (PER2::LUC) knockin mice, and immunochemistry of SCN from animals harvested at various circadian times, we assessed the spatiotemporal activation patterns of PER2 to explore the emergence of a coherent oscillation at the tissue level. The results indicate that circadian oscillation is characterized by a stable daily cycle of PER2 expression involving orderly serial activation of specific SCN subregions, followed by a silent interval, with substantial symmetry between the left and right side of the SCN. The biological significance of the clusters identified in living slices was confirmed by co-expression of LUC and PER2 in fixed, immunochemically stained brain sections, with the spatiotemporal pattern of LUC expression resembling that revealed in the cluster analysis of bioluminescent slices. We conclude that the precise timing of PER2 expression within individual neurons is dependent on their location within the nucleus, and that small groups of neurons within the SCN give rise to distinctive and identifiable subregions. We propose that serial activation of these subregions is the basis of robustness and resilience of the daily rhythm of the SCN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.