Evidence map›Paper›PMID 21488823›Full record

ReviewJournal of long-term effects of medical implants2010

Novel approaches to bone grafting: porosity, bone morphogenetic proteins, stem cells, and the periosteum.

Peter Petrochenko, Roger J Narayan

Abstract readReview
In one paragraph

Review in Journal of long-term effects of medical implants, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter PetrochenkoJoint Department of Biomedical Engineering, University of North Carolina, Raleigh, NC, USA. pepetroc@email.unc.edu
Roger J Narayan
UNC/NCSU Joint Department of Biomedical Engineering · US

Funding

Autonomous Treatment of Opioid AbuseR21DA026980 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NARAYAN, ROGER J · 2009 to 2010
$291k
NIDA NIH HHS R21 DA026980NIDA NIH HHS R21DA026980
6 · The paper itself

Abstract

The disadvantages involving the use of a patient's own bone as graft material have led surgeons to search for alternative materials. In this review, several characteristics of a successful bone graft material are discussed. In addition, novel synthetic materials and natural bone graft materials are being considered. Various factors can determine the success of a bone graft substitute. For example, design considerations such as porosity, pore shape, and interconnection play significant roles in determining graft performance. The effective delivery of bone morphogenetic proteins and the ability to restore vascularization also play significant roles in determining the success of a bone graft material. Among current approaches, shorter bone morphogenetic protein sequences, more efficient delivery methods, and periosteal graft supplements have shown significant promise for use in autograft substitutes or autograft extenders.

Indexed as

Bone and BonesBone Morphogenetic ProteinsBone SubstitutesBone TransplantationDrug Delivery SystemsHumansPeriosteumPorosityStem CellsTransplantation, HomologousBone Morphogenetic ProteinsBone Substitutes

Identifiers

PMID21488823
PMCPMC3181122
OpenAlexW2088727185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.