ReviewCurrent neurology and neuroscience reports2011
Alzheimer's genetics in the GWAS era: a continuing story of 'replications and refutations'.
Review in Current neurology and neuroscience reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses.Oncotarget · 2016Pooled it
- Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer's Disease.Frontiers in molecular neuroscience · 2018Review
- Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?Brain pathology (Zurich, Switzerland) · 2017Article
- 82-kDa choline acetyltransferase and SATB1 localize to β-amyloid induced matrix attachment regions.Scientific reports · 2016Article
- Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- Apolipoprotein E allelotype is associated with neuropathological findings in Alzheimer's disease.Virchows Archiv : an international journal of pathology · 2015Article
- At the interface of sensory and motor dysfunctions and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Review
- Article
- New genes and new insights from old genes: update on Alzheimer disease.Continuum (Minneapolis, Minn.) · 2013Review
- Exploratory analysis of seven Alzheimer's disease genes: disease progression.Neurobiology of aging · 2013Article
- Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD.Archives of medical research · 2012Review
- Article
- Data mining of high density genomic variant data for prediction of Alzheimer's disease risk.BMC medical genetics · 2012Article
- Clinico-pathological correlations of the most common neurodegenerative dementias.Frontiers in neurology · 2012Article
- Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Human molecular genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After a decade of intensive investigation but only few replicable results, Alzheimer's disease (AD) genetics research is slowly picking up pace. This is mostly owing to the completion of several genome-wide association studies (GWAS), which have suggested the existence of over three dozen potential new AD susceptibility genes. Although only a handful of these could be confirmed in subsequent independent replication efforts to date, this success rate is still much higher than in the pre-GWAS era. This review provides a brief summary of the principal methodologic advances in genetics research of the past decade, followed by a description of the most compelling findings that these advances have unearthed in AD. The paper closes with a discussion of the persistent methodologic difficulties and challenges and an outlook on what we can expect to gain from the next 10 years of AD genetics research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.