ReviewLangenbeck's archives of surgery2011
Molecular pathogenesis of nodular goiter.
Review in Langenbeck's archives of surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06868459 (Pressure-enabled Retrograde Occlusive Therapy With Embolization for Control of Thyroid Disease), which is not on this map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pressure-enabled Retrograde Occlusive Therapy With Embolization for Control of Thyroid Disease (PROTECT Registry): A Multicenter Registry
Who cites it
15 citing papers in PubMed, 71 citations in OpenAlex.
- Different fatty acid patterns in serum in patients with various thyroid diseases.Scientific reports · 2026Article
- Risk of Malignancy in Long-Standing Goiters: A Retrospective Study at Khartoum Teaching Hospital, Sudan.Cureus · 2025Article
- The Prevalence and Associated Predictors for Diabetes Mellitus in Adult Patients With Thyroid Nodules.Journal of clinical medicine research · 2023Article
- Is Melanoma Progression Affected by Thyroid Diseases?International journal of molecular sciences · 2022Review
- Article
- Thyroid diseases and skin autoimmunity.Reviews in endocrine & metabolic disorders · 2018Review
- Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer.International journal of endocrinology · 2017Article
- Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Article
- Oxidative stress and the ageing endocrine system.Nature reviews. Endocrinology · 2013Review
- Recent insights into the cell biology of thyroid angiofollicular units.Endocrine reviews · 2013Review
- The Impact of the D727E Polymorphism has no Significant Role in Multi Nodular Goiter.Balkan journal of medical genetics : BJMG · 2012Article
- Impact of surgical technique on operative morbidity and its socioeconomic benefit in thyroid surgery.Langenbeck's archives of surgery · 2012Article
- Endemic goiter--individual risk factors necessitate individual treatment.Langenbeck's archives of surgery · 2011Article
- An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter.Journal of family medicine and primary careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFamilial clustering of goiters mostly with an autosomal dominant pattern of inheritance has repeatedly been reported. Moreover, other environmental and etiologic factors are likely to be involved in the development of euthyroid goiter. Therefore, a multifactorial etiology based on complex interactions of both genetic predisposition and the individuals' environment is likely.
methodsThe line of events from early thyroid hyperplasia to multinodular goiter argues for the predominant neoplastic (i.e., originating from a single mutated cell) character of nodular structures. Etiologically, relevant somatic mutations are known in two thirds of papillary and follicular thyroid carcinomas and hot thyroid nodules. In contrast, the somatic mutations relevant for benign cold or benign isocaptant thyroid nodules which constitute the majority of thyroid nodules are unknown.
resultsThe nodular process is triggered by the oxidative nature of thyroid hormone synthesis or additional oxidative stress caused by iodine deficiency or smoking. If the antioxidant defense is not effective, this oxidative stress will cause DNA damage followed by an increase of the spontaneous mutation rate which is a substrate for tumorogenesis.
conclusionsTherefore, the hallmark of thyroid physiology--H(2)O(2) production during hormone synthesis--is very likely the ultimate cause for the frequent mutagenesis in the thyroid gland. Because iodine deficiency increases the oxidative burden, DNA damage and mutagenesis could provide the basis for the frequent nodular transformation of endemic goiters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.