Evidence map›Paper›PMID 21487925›Full record

ArticleEndocrine pathology2011

Uncommon GNAQ, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers.

Avaniyapuram Kannan Murugan, Jianli Dong, Jingwu Xie, Mingzhao Xing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. The Role of MMP8 in Cancer: A Systematic Review.International journal of molecular sciences · 2019
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Molecular Diagnostics and [Thyroid : official journal of the American Thyroid Association · 2024
    Trial
  5. Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K-mutated melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013
    Trial
  6. LncRNAFrontiers in endocrinology · 2026
    Article
  7. EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. Article
  9. Article
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  12. Article
  13. Analysis ofMolecular and clinical oncology · 2021
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Avaniyapuram Kannan MuruganLaboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, 1830, East Monument Street, Suite 333, Baltimore, MD 21287, USA.
Jianli Dong
Jingwu Xie
Mingzhao Xing
Johns Hopkins University · USIndiana University · USThe University of Texas Medical Branch at Galveston · US

Funding

Genetic & Epigenetic Events in Papillary Thyroid CancerR01CA113507 · NCI · JOHNS HOPKINS UNIVERSITY · PI XING, MICHAEL MINGZHAO · 2006 to 2015
$2.2M
Molecular Events in the PI3K/Akt Pathway in Thyroid CancerR01CA134225 · NCI · JOHNS HOPKINS UNIVERSITY · PI XING, MICHAEL MINGZHAO · 2009 to 2013
$1.6M
NCI NIH HHS R01 CA113507NCI NIH HHS R01 CA134225NCI NIH HHS R01CA134225
6 · The paper itself

Abstract

Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1 genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.

Indexed as

MutationBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesErbB ReceptorsGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11Matrix Metalloproteinase 8Neoplasm ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktThyroid NeoplasmsAKT3 protein, humanBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesEGFR protein, humanErbB ReceptorsGNAQ protein, humanGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11Matrix Metalloproteinase 8MMP8 protein, humanNeoplasm ProteinsPhosphatidylinositol 3-KinasesPIK3CA protein, humanProto-Oncogene Proteins c-akt

Identifiers

PMID21487925
PMCPMC3133631
OpenAlexW1975852572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.