ArticleClinical and experimental medicine2011
Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients.
Article in Clinical and experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Combined assessment of 25(OH)D, CD4Frontiers in immunology · 2026Article
- Neutrophils in colorectal cancer: mechanisms, prognostic value, and therapeutic implications.Frontiers in immunology · 2025Review
- IL-22, a vital cytokine in autoimmune diseases.Clinical and experimental immunology · 2024Review
- Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus.Inflammation · 2023Article
- T Cells in Systemic Lupus Erythematosus.Rheumatic diseases clinics of North America · 2021Review
- Elevated levels of CCR6Scientific reports · 2017Article
- AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis.Journal of autoimmunity · 2016Article
- T cell subsets and their signature cytokines in autoimmune and inflammatory diseases.Cytokine · 2015Review
- The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.The Journal of clinical investigation · 2014Article
- Targeting interleukin-22 in psoriasis.Inflammation · 2014Review
- A higher frequency of circulating IL-22(+)CD4(+) T cells in Chinese patients with newly diagnosed Hashimoto's thyroiditis.PloS one · 2014Article
- Emerging role of interleukin-22 in autoimmune diseases.Cytokine & growth factor reviews · 2013Review
- A high frequency of circulating th22 and th17 cells in patients with new onset graves' disease.PloS one · 2013Article
- Increased expression of IL-22 is associated with disease activity in Behcet's disease.PloS one · 2013Article
- Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer.Journal of clinical immunology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, Th17 cell-associated responses have received growing attention; however, the role of IL-22 (a cytokines also produced by Th17 cells) in the pathogenesis of systemic lupus erythematosus (SLE) has not been widely explored. In this study, we analyze the frequencies of IL-22-positive CD4+/CD8+ T cells in peripheral blood mononuclear cells (PBMCs) from patients with SLE and their correlations with disease activity and clinical data. Five-color flow cytometry (FCM) was used to assess IL-22 production of CD4+/CD8+ T cells in PBMCs from 31 patients with SLE and 22 healthy control subjects, following stimulation ex vivo with phorbol 12-myristate 13-acetate and ionomycin for 4 h. Results showed that the percentages of IL-22-positive CD4+ T cells were increased in the PBMCs of patients with SLE compared with healthy control subjects, whereas there were no significant differences in the percentages of IL-22-positive CD8+ T cells. There was a strong positive correlation between the proportion of CD4+ T cells expressing IL-22 and SLEDAI score (r (s) = 0.65, P < 0.001). Furthermore, the frequencies of IL-22-positive CD4+ T cells were significantly higher in patients with SLE with nephritis than those without nephritis (Z = -2.72, P < 0.01). In conclusion, increased frequencies of IL-22-positive CD4+ T cells in patients with SLE and positive correlation with SLEDAI score and lupus nephritis suggest that this cytokine may be implicated in the pathogenesis of the disease.
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