ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Barrier protective effects of lycopene in human endothelial cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Drug-herb combination therapy in cancer management.Molecular biology reports · 2022Pooled it
- Marine Carotenoids: A Critical Review of Bioactivities, Bioavailability, and Therapeutic Potential.BioMed research international · 2025Review
- Lycopene supplementation reduces inflammatory, histopathological and DNA damage in an acute lung injury rabbit model.Critical care science · 2025Article
- The Antioxidant and Anti-Inflammatory Effects of the Main Carotenoids from Tomatoes via Nrf2 and NF-κB Signaling Pathways.Nutrients · 2023Article
- A New Target in Inflammatory Diseases: Lycopene.The Eurasian journal of medicine · 2022Article
- Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling.Antioxidants (Basel, Switzerland) · 2021Article
- Role of Polyphenols and Carotenoids in Endothelial Dysfunction: An Overview from Classic to Innovative Biomarkers.Oxidative medicine and cellular longevity · 2020Review
- Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response.Journal of neuroinflammation · 2019Article
- Bioactivities of phytochemicals present in tomato.Journal of food science and technology · 2018Review
- Lycopene and Vascular Health.Frontiers in pharmacology · 2018Review
- Carotenoids: biochemistry, pharmacology and treatment.British journal of pharmacology · 2017Review
- Suppressive effects of methylthiouracil on polyphosphate-mediated vascular inflammatory responses.Journal of cellular and molecular medicine · 2016Article
- Anti-inflammatory effects of vicenin-2 and scolymoside on polyphosphate-mediated vascular inflammatory responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Potential of Dietary Non-Provitamin A Carotenoids in the Prevention and Treatment of Diabetic Microvascular Complications.Advances in nutrition (Bethesda, Md.) · 2016Review
- Ameliorative Effect of Vicenin-2 and Scolymoside on TGFBIp-Induced Septic Responses.Inflammation · 2015Article
- Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Anti-Inflammatory Effects of Lysozyme Against HMGB1 in Human Endothelial Cells and in Mice.Inflammation · 2015Article
- Inhibitory effects of polyozellin from Polyozellus multiplex on HMGB1-mediated septic responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Antiseptic Effects of New 3'-N-Substituted Carbazole Derivatives In Vitro and In Vivo.Inflammation · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM AND
objectiveLycopene has antioxidant and anticancer effects but its barrier protective effects and underlying mechanism are not fully identified. The potential barrier protective roles of lycopene in lipopolysaccharide (LPS)-activated primary human umbilical vein endothelial cells (HUVECs) were investigated.
methodsWe determined the barrier protective effects of lycopene, such as permeability, leukocyte adhesion and migration, and activation of proinflammatory proteins in LPS-activated HUVECs.
resultsLycopene inhibited vascular barrier permeability, expression of cell adhesion molecules, leukocyte adhesion and transendothelial migration in LPS-activated HUVECs. Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-α) and activation of nuclear factor-κB (NF-κB), CD14 and Toll-like receptor-4 (TLR4).
conclusionThese findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-κB, CD14 and TLR4 expression and production of TNF-α, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.