ReviewPflugers Archiv : European journal of physiology2011
Mechanical modulation of cardiac microtubules.
Review in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Why the septum thickens in hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Review
- Functional and structural differences between skinned and intact muscle preparations.The Journal of general physiology · 2022Review
- Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure.Frontiers in cell and developmental biology · 2022Review
- Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice.Frontiers in physiology · 2020Article
- From isolated structures to continuous networks: A categorization of cytoskeleton-based motile engineered biological microstructures.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Mechano-chemo-transduction in cardiac myocytes.The Journal of physiology · 2017Review
- The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile.International journal of nanomedicine · 2017Article
- Spontaneous Formation of a Globally Connected Contractile Network in a Microtubule-Motor System.Biophysical journal · 2016Article
- Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.Science (New York, N.Y.) · 2016Article
- Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes.Cell reports · 2016Article
- Reproducible ion-current-based approach for 24-plex comparison of the tissue proteomes of hibernating versus normal myocardium in swine models.Journal of proteome research · 2014Article
- Fucoidan promotes early step of cardiac differentiation from human embryonic stem cells and long-term maintenance of beating areas.Tissue engineering. Part A · 2014Article
- cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.The Journal of biological chemistry · 2014Article
- X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i.Journal of molecular and cellular cardiology · 2013Review
- Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension.Journal of molecular and cellular cardiology · 2013Article
- Sacrificial layer technique for axial force post assay of immature cardiomyocytes.Biomedical microdevices · 2013Article
- Microtubules and angiotensin II receptors contribute to modulation of repolarization induced by ventricular pacing.Heart rhythm · 2012Article
- Cardiac-specific deletion of the microtubule-binding protein CENP-F causes dilated cardiomyopathy.Disease models & mechanisms · 2012Article
- The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue.Pflugers Archiv : European journal of physiology · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules are a major component of the cardiac myocyte cytoskeleton. Interventions that alter it may influence cardiac mechanical and electrical activity by disrupting the trafficking of proteins to and from the surface membrane by molecular motors such as dynein, which use microtubules as tracks to step along. Free tubulin dimers may transfer GTP to the α-subunits of G-proteins, thus an increase in free tubulin could increase the activity of G-proteins; evidence for and against such a role exists. There is more general agreement that microtubules act as compression-resisting structures within myocytes, influencing visco-elasticity of myocytes and increasing resistance to shortening when proliferated and resisting deformation from longitudinal shear stress. In response to pressure overload, there can be post-translational modifications resulting in more stable microtubules and an increase in microtubule density. This is accompanied by contractile dysfunction of myocytes which can be reversed by microtubule disruption. There are reports of mechanically induced changes in electrical activity that are dependent upon microtubules, but at present, a consensus is lacking on whether disruption or proliferation would be beneficial in the prevention of arrhythmias. Microtubules certainly play a role in the response of cardiac myocytes to mechanical stimulation, the exact nature and significance of this role is still to be fully determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.