ArticleBiomedical microdevices2011
Lipid bilayer coated Al(2)O(3) nanopore sensors: towards a hybrid biological solid-state nanopore.
Article in Biomedical microdevices, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Membrane curvature enhances oxidation within lipid bilayers in a composition-dependent manner.Biophysical journal · 2026Article
- Membrane curvature enhances oxidation within lipid bilayers in a composition-dependent manner.bioRxiv : the preprint server for biology · 2026Article
- The NEOtrap - en route with a new single-molecule technique.iScience · 2021Review
- Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.Critical reviews in biomedical engineering · 2020Review
- Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range.RSC advances · 2019Article
- Characterization of the Lipid Structure and Fluidity of Lipid Membranes on Epitaxial Graphene and Their Correlation to Graphene Features.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Lipid Bilayer Membrane in a Silicon Based Micron Sized Cavity Accessed by Atomic Force Microscopy and Electrochemical Impedance Spectroscopy.Biosensors · 2017Article
- A tip-attached tuning fork sensor for the control of DNA translocation through a nanopore.The Review of scientific instruments · 2017Article
- Nanopore Sensing.Analytical chemistry · 2017Review
- Electrochemical impedance spectroscopy for black lipid membranes fused with channel protein supported on solid-state nanopore.European biophysics journal : EBJ · 2016Article
- Fabrication of Solid State Nanopore in Thin Silicon Membrane Using Low Cost Multistep Chemical Etching.Materials (Basel, Switzerland) · 2015Article
- Ionic conductivity, structural deformation, and programmable anisotropy of DNA origami in electric field.ACS nano · 2015Article
- Slowing DNA Transport Using Graphene-DNA Interactions.Advanced functional materials · 2015Article
- Graphene nanopore support system for simultaneous high-resolution AFM imaging and conductance measurements.ACS applied materials & interfaces · 2014Article
- Highly parallel transport recordings on a membrane-on-nanopore chip at single molecule resolution.Nano letters · 2014Article
- Engineering lipid bilayer membranes for protein studies.International journal of molecular sciences · 2013Review
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Miniaturized technology for protein and nucleic acid point-of-care testing.Translational research : the journal of laboratory and clinical medicine · 2012Review
- GPU/CPU Algorithm for Generalized Born/Solvent-Accessible Surface Area Implicit Solvent Calculations.Journal of chemical theory and computation · 2012Article
- Stacked graphene-Al2O3 nanopore sensors for sensitive detection of DNA and DNA-protein complexes.ACS nano · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
Solid-state nanopore sensors are highly versatile platforms for the rapid, label-free electrical detection and analysis of single molecules, applicable to next generation DNA sequencing. The versatility of this technology allows for both large scale device integration and interfacing with biological systems. Here we report on the development of a hybrid biological solid-state nanopore platform that incorporates a highly mobile lipid bilayer on a single solid-state Al(2)O(3) nanopore sensor, for the potential reconstitution of ion channels and biological nanopores. Such a system seeks to combine the superior electrical, thermal, and mechanical stability of Al(2)O(3) solid-state nanopores with the chemical specificity of biological nanopores. Bilayers on Al(2)O(3) exhibit higher diffusivity than those formed on TiO(2) and SiO(2) substrates, attributed to the presence of a thick hydration layer on Al(2)O(3), a key requirement to preserving the biological functionality of reconstituted membrane proteins. Molecular dynamics simulations demonstrate that the electrostatic repulsion between the dipole of the DOPC headgroup and the positively charged Al(2)O(3) surface may be responsible for the enhanced thickness of this hydration layer. Lipid bilayer coated Al(2)O(3) nanopore sensors exhibit excellent electrical properties and enhanced mechanical stability (GΩ seals for over 50 h), making this technology ideal for use in ion channel electrophysiology, the screening of ion channel active drugs and future integration with biological nanopores such as α-hemolysin and MspA for rapid single molecule DNA sequencing. This technology can find broad application in bio-nanotechnology.
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