ArticleArchives of virology2011
Cloning the simian varicella virus genome in E. coli as an infectious bacterial artificial chromosome.
Article in Archives of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Insertion of foreign genes into the simian varicella virus genome by Tn7-mediated site-specific transposition.Journal of virological methods · 2024Article
- Review
- Simian Varicella Virus DNA in Saliva and Buccal Cells After Experimental Acute Infection in Rhesus Macaques.Frontiers in microbiology · 2019Article
- Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.Journal of virology · 2018Article
- Varicella Virus-Host Interactions During Latency and Reactivation: Lessons From Simian Varicella Virus.Frontiers in microbiology · 2018Review
- Simian varicella virus inhibits the interferon gamma signalling pathway.The Journal of general virology · 2017Article
- Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques.Clinical and experimental immunology · 2015Article
- The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation.Journal of virology · 2015Article
- Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms.PLoS pathogens · 2015Article
- Abortive intrabronchial infection of rhesus macaques with varicella-zoster virus provides partial protection against simian varicella virus challenge.Journal of virology · 2015Article
- Intrabronchial infection of rhesus macaques with simian varicella virus results in a robust immune response in the lungs.Journal of virology · 2014Article
- Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivo.Virology journal · 2013Article
- Age and immune status of rhesus macaques impact simian varicella virus gene expression in sensory ganglia.Journal of virology · 2013Article
- T-Cell tropism of simian varicella virus during primary infection.PLoS pathogens · 2013Article
- Attenuation of the adaptive immune response in rhesus macaques infected with simian varicella virus lacking open reading frame 61.Journal of virology · 2013Article
- Recombinant varicella-zoster virus vaccines as platforms for expression of foreign antigens.Advances in virology · 2013Article
- Viral bacterial artificial chromosomes: generation, mutagenesis, and removal of mini-F sequences.Journal of biomedicine & biotechnology · 2012Review
- Optimization of transfection methods for Huh-7 and Vero cells: A comparative study.Cytology and genetics · 2012Article
- Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture.Journal of neurovirology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Simian varicella virus (SVV) is closely related to human varicella-zoster virus and causes varicella and zoster-like disease in nonhuman primates. In this study, a mini-F replicon was inserted into a SVV cosmid, and infectious SVV was generated by co-transfection of Vero cells with overlapping SVV cosmids. The entire SVV genome, cloned as a bacterial artificial chromosome (BAC), was stably propagated upon serial passage in E. coli. Transfection of pSVV-BAC DNA into Vero cells yielded infectious SVV (rSVV-BAC). The mini-F vector sequences flanked by loxP sites were removed by co-infection of Vero cells with rSVV-BAC and adenovirus expressing Cre-recombinase. Recombinant SVV generated using the SVV-BAC genetic system has similar molecular and in vitro replication properties as wild-type SVV. To demonstrate the utility of this approach, a SVV ORF 10 deletion mutant was created using two-step Red-mediated recombination. The results indicate that SVV ORF 10, which encodes a homolog of the HSV-1 virion VP-16 transactivator protein, is not essential for in vitro replication but is required for optimal replication in cell culture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.