ArticlePsychopharmacology2011
The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 68 citations in OpenAlex.
- Short-term nicotine deprivation alters dorsal anterior cingulate glutamate concentration and concomitant cingulate-cortical functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Hippocampal ring finger protein 10-dependent signaling supports cognitive flexibility.iScience · 2026Article
- Nicotine Reprograms Aging-Related Metabolism and Protects Against Motor Decline in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Protracted neurobehavioral and microRNA deficits by acute nicotine dependence in mice.Communications biology · 2024Article
- Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.Biology of sex differences · 2024Article
- Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference.Brain sciences · 2024Article
- Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence.Behavioral and brain functions : BBF · 2024Article
- Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).Molecular autism · 2022Article
- Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.Molecular neurobiology · 2021Article
- Rodent models for nicotine withdrawal.Journal of psychopharmacology (Oxford, England) · 2021Review
- Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons.Addiction biology · 2021Article
- Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning.Genes, brain, and behavior · 2021Article
- Nicotine Gateway Effects on Adolescent Substance Use.The western journal of emergency medicine · 2019Review
- Nicotinic Acetylcholine Receptor Ligands, Cognitive Function, and Preclinical Approaches to Drug Discovery.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Review
- Cholinergic modulation of spatial learning, memory and navigation.The European journal of neuroscience · 2018Review
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
- Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.Molecular psychiatry · 2017Article
- Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice.PloS one · 2017Article
- Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults.Brain research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
rationaleSpatial and novel object recognition learning is different from learning that uses aversive or appetitive stimuli to shape acquisition because no overt contingencies are needed. While this type of learning occurs on a daily basis, little is known about how nicotine administration affects it.
objectivesTo determine the effects of acute, chronic, and withdrawal from chronic nicotine on two related but distinct incidental learning tasks, novel and spatial object recognition.
methodsIn C57BL/6J mice, the effects of acute (0.045-0.18 mg/kg), chronic (6.3 mg/kg/day), and withdrawal from chronic nicotine on novel and spatial object recognition were examined.
resultsWith a 48-h delay between training and testing, acute nicotine enhanced spatial (difference score, saline = 3.34 s, nicotine = 7.71 s, p = 0.029) but resulted in a deficit in novel object recognition (difference score, saline = 8.76 s, nicotine = 4.48 s, p = 0.033). Chronic nicotine resulted in a strong trend towards a deficit in spatial object recognition (difference score, saline = 4.01 s, nicotine = 1.81 s, p = 0.059) but had no effect on novel object recognition, and withdrawal from chronic nicotine disrupted spatial object recognition (difference score, saline = 3.00 s, nicotine = 0.17 s, p = 0.004) but had no effect on novel object recognition.
conclusionsThe effects of nicotine on spatial object recognition shift from enhancement to deficit as administration changes from acute to chronic and withdrawal. These effects were specific for spatial object recognition, which may be due to differing underlying neural substrates involved in these tasks. Understanding how nicotine alters learning has implications for understanding diseases associated with altered cholinergic function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.