Evidence map›Paper›PMID 21487576›Full record

ArticleLab on a chip2011

Hybrid electrokinetic manipulation in high-conductivity media.

Jian Gao, Mandy L Y Sin, Tingting Liu, Vincent Gau, Joseph C Liao, Pak Kin Wong

Abstract read
In one paragraph

Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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  14. Long-range electrothermal fluid motion in microfluidic systems.International journal of heat and mass transfer · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jian GaoDepartment of Aerospace and Mechanical Engineering, University of Arizona, Tucson, Arizona 85721, USA.
Mandy L Y Sin
Tingting Liu
Vincent Gau
Joseph C Liao
Pak Kin Wong

Funding

An Integrated Diagnostic Biochip for Point of Care Pathogen IdentificationU01AI082457 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI LIAO, JOSEPH C · 2009 to 2013
$3.7M
An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility TestingR44AI088756 · NIAID · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2012 to 2014
$3.0M
Mechanoregulation of Tissue MorphogenesisDP2OD007161 · OD · UNIVERSITY OF ARIZONA · PI WONG, PAK KIN · 2010 to 2010
$2.3M
Rapid Antimicrobial Susceptibility Test Cartridge for Resource-Limited SettingsR43AI088756 · NIAID · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2010 to 2011
$700k
Rapid Antibiotic Susceptibility Testing for Neonatal Intensive UnitsR43HD065303 · NICHD · GENEFLUIDICS, INC. · PI GAU, VINCENT JEN-JR · 2010 to 2011
$434k
NIAID NIH HHS 1U01AI082457-01NIAID NIH HHS R43 AI088756NIAID NIH HHS R43AI088756-01NIAID NIH HHS R44 AI088756NIAID NIH HHS U01 AI082457NICHD NIH HHS R43 HD065303NICHD NIH HHS R43HD065303-01NIH HHS 1DP2OD007161-01NIH HHS DP2 OD007161
6 · The paper itself

Abstract

This study reports a hybrid electrokinetic technique for label-free manipulation of pathogenic bacteria in biological samples toward medical diagnostic applications. While most electrokinetic techniques only function in low-conductivity buffers, hybrid electrokinetics enables effective operation in high-conductivity samples, such as physiological fluids (∼1 S m(-1)). The hybrid electrokinetic technique combines short-range electrophoresis and dielectrophoresis, and long-range AC electrothermal flow to improve its effectiveness. The major technical hurdle of electrode instability for manipulating high conductivity samples is tackled by using a Ti-Au-Ti sandwich electrode and a 3-parallel-electrode configuration is designed for continuous isolation of bacteria. The device operates directly with biological samples including urine and buffy coats. We show that pathogenic bacteria and biowarfare agents can be concentrated for over 3 orders of magnitude using hybrid electrokinetics.

Indexed as

BacteriaElectric ConductivityElectrodesElectrophoresisGoldKineticsMicrofluidic Analytical TechniquesTitaniumGoldTitanium

Identifiers

PMID21487576
PMCPMC4084846

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.