Evidence map›Paper›PMID 21487430›Full record

ReviewNature reviews. Cardiology2011

Infective endocarditis.

Yok-Ai Que, Philippe Moreillon

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 113 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 4 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02454413 nacompletednot on this mapstarted 2013, after this paper: background citation

Assessment of the impact of cleaning methods and overnight denture storage on biofilm formation on removable acrylic dentures.

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2013 to 2013Enrolled13ConditionsDenture HygieneArmsdenture brushing with water and soap, ultrasonic denture cleaning, cleansing tablet
NCT06330766 unknown statusnot on this mapstarted 2020, after this paper: background citation

Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Transcatheter Aortic Valve Implantation: a Prospective Observational Study

Typeobservational_patient_registrySponsorOdense University HospitalRan2020 to 2026Enrolled1,000ConditionsTranscatheter Aortic Valve Implantation, Dental, EndocarditisArmsNo preoperative dental screening
NCT06403839 recruitingnot on this mapstarted 2020, after this paper: background citation

Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Surgical Valve Replacement: a Prospective Observational Study

TypeobservationalSponsorOdense University HospitalRan2020 to 2028Enrolled1,000ConditionsSurgical Valve Replacement, Dental, EndocarditisArmsNo preoperative dental screening
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 243 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Novel Interaction of Staphylococcal Protein A With Human Fibronectin and Its Implications in Host Cell Adhesion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. The Application of Rat Models inPathogens (Basel, Switzerland) · 2024
    Review
  18. Pathogens (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Review

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yok-Ai QueDepartment of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue du Bugnon 46, Lausanne, Switzerland.
Philippe Moreillon
University Hospital of Lausanne · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infective endocarditis (IE) is lethal if not aggressively treated with antibiotics alone or in combination with surgery. The epidemiology of this condition has substantially changed over the past four decades, especially in industrialized countries. Once a disease that predominantly affected young adults with previously well-identified valve disease--mostly chronic rheumatic heart disease--IE now tends to affect older patients and new at-risk groups, including intravenous-drug users, patients with intracardiac devices, and patients exposed to healthcare-associated bacteremia. As a result, skin organisms (for example, Staphylococcus spp.) are now reported as the pathogen in these populations more often than oral streptococci, which still prevail in the community and in native-valve IE. Moreover, progress in molecular diagnostics has helped to improve the diagnosis of poorly cultivable pathogens, such as Bartonella spp. and Tropheryma whipplei, which are responsible for blood-culture-negative IE more often than expected. Epidemiological data indicate that IE mostly occurs independently of medico-surgical procedures, and that circumstantial antibiotic prophylaxis is likely to protect only a minute proportion of individuals at risk. Therefore, new strategies to prevent IE--including improvement of dental hygiene, decontamination of carriers of Staphylococcus aureus, vaccination, and, possibly, antiplatelet therapy--must be explored.

Indexed as

Endocarditis, BacterialAnti-Bacterial AgentsAntibiotic ProphylaxisCardiac Surgical ProceduresDrug Resistance, BacterialHumansPredictive Value of TestsRisk FactorsTreatment OutcomeAnti-Bacterial Agents

Identifiers

PMID21487430
OpenAlexW4210970544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.