ReviewNature reviews. Neurology2011
Clinical and pathological features of alcohol-related brain damage.
Review in Nature reviews. Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 366 citations in OpenAlex.
- Cathodal Transcranial Direct Current Stimulation Does Not Change Implicit Associations Against Alcohol in Alcohol Use Disorder: A Preregistered Clinical Trial.Addiction biology · 2025Trial
- Virtual Reality Cognitive Training Among Individuals With Alcohol Use Disorder Undergoing Residential Treatment: Pilot Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Electroacupuncture Ameliorates Alcohol-Related Cognitive Impairment by Modulating the Gut-Brain Axis to Alleviate LPS Driven Neuroinflammation.CNS neuroscience & therapeutics · 2026Article
- Beyond total BDNF: The proBDNF/mBDNF balance in substance use disorders.Neurobiology of disease · 2026Review
- Cognitive Performance After Kidney and Liver Transplantation: A Cross-Sectional Study Using Addenbrooke's Cognitive Examination III.Journal of clinical medicine · 2026Article
- Efficacy of thiamine (vitamin B1) in sepsis and septic shock: A meta-analysis of randomized controlled trials.Clinics (Sao Paulo, Brazil) · 2026Review
- Ultra-processed food intake and cognitive decline in older adults.European journal of nutrition · 2026Article
- See One, B1, Treat One: Identifying and Managing Thiamine Deficiency in a Patient With Altered Mental Status.Cureus · 2026Article
- Thiamine Deficiency and Brain Injury: Neuroanatomical Changes in the Wernicke-Korsakoff Syndrome.Cureus · 2025Review
- Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice.Metabolic brain disease · 2025Article
- Non-Linear Relationship Between Alcohol Consumption and Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Presenting to the Emergency Department.Journal of Korean medical science · 2025Observational
- Suppression of NF-κB/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation.Journal of leukocyte biology · 2025Article
- A Brief Cognitive Behavioral Therapy-Based Digital Intervention for Reducing Hazardous Alcohol Use in South Korea: Development and Prospective Pilot Study.JMIR formative research · 2025Article
- Encephalomalacia from Physical Trauma in an Adult: A Case Report and Review of Literature.International medical case reports journal · 2025Article
- Cognitive Performance in Patients With Alcohol-Associated Liver Disease Undergoing Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Enlarged perivascular spaces in alcohol-related brain damage induced by dyslipidemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Protective effect ofNutrition research and practice · 2024Article
- Protein Kinase C (PKC) in Neurological Health: Implications for Alzheimer's Disease and Chronic Alcohol Consumption.Brain sciences · 2024Review
- Alcohol Triggers the Accumulation of Oxidatively Damaged Proteins in Neuronal Cells and Tissues.Antioxidants (Basel, Switzerland) · 2024Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
One of the sequelae of chronic alcohol abuse is malnutrition. Importantly, a deficiency in thiamine (vitamin B(1)) can result in the acute, potentially reversible neurological disorder Wernicke encephalopathy (WE). When WE is recognized, thiamine treatment can elicit a rapid clinical recovery. If WE is left untreated, however, patients can develop Korsakoff syndrome (KS), a severe neurological disorder characterized by anterograde amnesia. Alcohol-related brain damage (ARBD) describes the effects of chronic alcohol consumption on human brain structure and function in the absence of more discrete and well-characterized neurological concomitants of alcoholism such as WE and KS. Through knowledge of both the well-described changes in brain structure and function that are evident in alcohol-related disorders such as WE and KS and the clinical outcomes associated with these changes, researchers have begun to gain a better understanding of ARBD. This Review examines ARBD from the perspective of WE and KS, exploring the clinical presentations, postmortem brain pathology, in vivo MRI findings and potential molecular mechanisms associated with these conditions. An awareness of the consequences of chronic alcohol consumption on human behavior and brain structure can enable clinicians to improve detection and treatment of ARBD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.