ArticleThe EMBO journal2011
LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis.Cellular & molecular immunology · 2024Article
- Review
- Protein 4.1R negatively regulates CD8Immunology · 2019Article
- LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells.Cell research · 2019Article
- Molecular cloning, polymorphism, and expression analysis of the LKB1/STK11 gene and its association with non-specific digestive disorder in rabbits.Molecular and cellular biochemistry · 2018Article
- SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.Aging and disease · 2018Article
- Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCRScientific reports · 2017Article
- Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.Cell chemical biology · 2017Article
- Protein kinase D regulates positive selection of CD4Nature communications · 2016Article
- Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.Nature · 2016Article
- An Lck-cre transgene accelerates autoantibody production and lupus development in (NZB × NZW)F1 mice.Lupus · 2016Article
- LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.EMBO reports · 2015Article
- MicroRNA-17 promotes normal ovarian cancer cells to cancer stem cells development via suppression of the LKB1-p53-p21/WAF1 pathway.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.Cell death & disease · 2014Article
- LKB1 mediates the development of conventional and innate T cells via AMP-dependent kinase autonomous pathways.PloS one · 2013Article
- mTOR and metabolic pathways in T cell quiescence and functional activation.Seminars in immunology · 2012Review
- Germinal center kinases in immune regulation.Cellular & molecular immunology · 2012Review
- Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.Nature immunology · 2012Article
- Regulation and function of mTOR signalling in T cell fate decisions.Nature reviews. Immunology · 2012Review
- The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serine/threonine kinase LKB1 is a tumour suppressor that regulates cell growth, polarity, and proliferation in many different cell types. We previously demonstrated that LKB1 controls thymocyte survival via regulation of AMPK activation. In this study, we show that LKB1 was also involved in thymocyte positive selection through regulation of T cell receptor (TCR) signalling. Both Lck-Cre- and CD4-Cre-mediated deletion of LKB1 impaired the generation of mature CD4 and CD8 single positive (SP) thymocytes that might have resulted from the attenuated tyrosine phosphorylation of phospholipase C-γ 1 (PLCγ1) in the absence of LKB1. We found that LKB1 was directly phosphorylated by Lck at tyrosine residues 36, 261, and 365 and predominately interacted with LAT and PLCγ1 following TCR stimulation. Loss of LKB1 led to impaired recruitment of PLCγ1 to the LAT signalosome. Correlatively, LKB1-deficient thymocytes failed to upregulate lineage-specifying factors, and to differentiate into SP thymocytes even if their impaired survival was rescued. These observations indicated that LKB1 is a critical component involved in TCR signalling, and our studies provide novel insights into the mechanisms of LKB1-mediated thymocyte development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.