Trial reportBMJ (Clinical research ed.)1990
Lipoprotein (a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men.
Trial report in BMJ (Clinical research ed.), 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The relationship between Lp(a) and CVD outcomes: a systematic review.Lipids in health and disease · 2016Pooled it
- Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.JAMA · 2009 · on this mapPooled it
- Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study).Diabetes care · 2011Trial
- Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a).British journal of sports medicine · 2004Trial
- Plant sterol esters lower plasma lipids and most carotenoids in mildly hypercholesterolemic adults.Lipids · 2002Trial
- Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives.International journal of environmental research and public health · 2023Review
- Lipoprotein(a): Just an Innocent Bystander in Arterial Hypertension?International journal of molecular sciences · 2023Review
- Lipoprotein(a) is Associated with Cardiovascular Events in Low Risk Males: Results from a Health Checkup Cohort with Long-Term Follow-Up.Acta Cardiologica Sinica · 2022Article
- Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.Journal of lipid research · 2016Review
- Serum ferritin is an independent factor in coronary artery stenosis among hemodialysis patients.International journal of hematology · 2016Article
- HyperLp(a)lipoproteinaemia: unmet need of diagnosis and treatment?Blood transfusion = Trasfusione del sangue · 2016Article
- Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.Indian journal of clinical biochemistry : IJCB · 2016Review
- Correlation analysis between serum lipoprotein (a) and the incidence of aortic valve sclerosis.International journal of clinical and experimental medicine · 2015Article
- Testosterone and insulin resistance in the metabolic syndrome and T2DM in men.Nature reviews. Endocrinology · 2013Article
- Lipoprotein(a) in cardiovascular diseases.BioMed research international · 2013Review
- Niacin: another look at an underutilized lipid-lowering medication.Nature reviews. Endocrinology · 2012Review
- Enigmatic role of lipoprotein(a) in cardiovascular disease.Clinical and translational science · 2010Article
- Determination of lipoprotein(a) kringle repeat number from genomic DNA: copy number variation genotyping using qPCR.Journal of lipid research · 2009Article
- Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular events.Journal of the American College of Cardiology · 2008Article
- Novel markers of inflammation in atherosclerosis.Current atherosclerosis reports · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between the serum lipoprotein (a) concentration and subsequent coronary heart disease.
designProspective case-control study based on a six year follow up of a general population sample of men aged 50 at baseline in 1983-4. Serum samples were frozen at the time of the baseline examination and kept at -70 degrees C for six years, after which the lipoprotein (a) concentrations in the samples were measured in cases and controls.
settingCity of Gothenburg, Sweden. SUBJECTS: 26 Men, from a general population sample of 776 men, who had sustained a myocardial infarction or died of coronary heart disease during the six years and 109 randomly selected controls from the same sample who had remained free of myocardial infarction. In neither cases nor controls was there a history of myocardial infarction at baseline.
main outcome measuresProportion of myocardial infarction or deaths from coronary heart disease, or both, in relation to the serum lipoprotein (a) concentration.
resultsMen who suffered coronary heart disease had significantly higher serum lipoprotein (a) concentrations than controls (mean difference 105 mg/l; 95% confidence interval 18 to 192 mg/l). Men with the highest fifth of serum lipoprotein (a) concentrations (cut off point 365 mg/l) suffered a coronary heart disease rate which was more than twice that of men with the lowest four fifths of concentrations. Logistic regression analysis showed the serum lipoprotein (a) concentration to be significantly associated with coronary heart disease independently of other risk factors.
conclusionThe serum lipoprotein (a) concentration in middle aged men is an independent risk factor for subsequent myocardial infarction or death from coronary heart disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.