ArticleEndocrinology2011
SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- GnRH and Cognition.Endocrinology · 2025Review
- Unusual suspects: Glial cells in fertility regulation and their suspected role in polycystic ovary syndrome.Journal of neuroendocrinology · 2022Review
- GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.Nature neuroscience · 2021Article
- Puberty, A Sensitive Window of Hypothalamic Development and Plasticity.Endocrinology · 2021Review
- Brain region-dependent alterations in polysialic acid immunoreactivity across the estrous cycle in mice.Hormones and behavior · 2020Article
- Oligodendrocytes express synaptic proteins that modulate myelin sheath formation.Nature communications · 2019Article
- Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice.PLoS biology · 2019Article
- Hypothalamic epigenetics driving female puberty.Journal of neuroendocrinology · 2018Review
- Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease.Frontiers in cellular neuroscience · 2018Article
- Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword.Frontiers in molecular neuroscience · 2018Review
- Article
- Redundant Postsynaptic Functions of SynCAMs 1-3 during Synapse Formation.Frontiers in molecular neuroscience · 2017Article
- Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis.Frontiers in physiology · 2015Article
- Epigenetic regulation of female puberty.Frontiers in neuroendocrinology · 2015Review
- A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates.Hormones and behavior · 2013Review
- Astrocyte-specific disruption of SynCAM1 signaling results in ADHD-like behavioral manifestations.PloS one · 2012Article
- Hypothalamic glial-to-neuronal signaling during puberty: influence of alcohol.International journal of environmental research and public health · 2011Review
- The synaptic cell adhesion molecule, SynCAM1, mediates astrocyte-to-astrocyte and astrocyte-to-GnRH neuron adhesiveness in the mouse hypothalamus.Endocrinology · 2011Article
- Gliotransmission by prostaglandin e(2): a prerequisite for GnRH neuronal function?Frontiers in endocrinology · 2011Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Female sexual maturation requires erythroblastosis B (erbB)4 signaling in hypothalamic astrocytes; however, the mechanisms by which erbB4 contributes to this process are incompletely understood. Here we show that SynCAM1, a synaptic adhesion molecule with signaling capabilities, is not only expressed highly in neurons, but also in hypothalamic astrocytes and is functionally associated with erbB4 receptor activity. Whereas SynCAM1 expression is diminished in astrocytes with impaired erbB4 signaling, ligand-dependent activation of astroglial erbB4 receptors results in rapid association of erbB4 with SynCAM1 and activation of SynCAM1 gene transcription. To determine whether astrocytic SynCAM1-dependent intracellular signaling is required for normal female reproductive function, we generated transgenic mice that express in an astrocyte-specific manner a dominant-negative form of SynCAM1 lacking the intracellular domain. The mutant protein was correctly targeted to the cell membrane and was functionally viable as shown by its ability to block intracellular calcium/calmodulin-dependent serine protein kinase redistribution, a major SynCAM1-mediated event. Dominant-negative-SynCAM1 female mice had a delayed onset of puberty, disrupted estrous cyclicity, and reduced fecundity. These deficits were associated with a reduced capacity of neuregulin-dependent erbB4 receptor activation to elicit prostaglandin E2 release from astrocytes and GnRH release from the hypothalamus. We conclude that one of the mechanisms underlying erbB4 receptor-mediated facilitation of glial-neuronal interactions in the neuroendocrine brain involves SynCAM1-dependent signaling and that this interaction is required for normal female reproductive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.