ArticleThe Journal of physiology2011
Developmental changes in propagation patterns and transmitter dependence of waves of spontaneous activity in the mouse cerebral cortex.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex.Nature communications · 2025Article
- Early-life maturation of the somatosensory cortex: sensory experience and beyond.Frontiers in neural circuits · 2024Review
- Synchronous excitation in the superficial and deep layers of the medial entorhinal cortex precedes early sharp waves in the neonatal rat hippocampus.Frontiers in cellular neuroscience · 2024Article
- Mesoscale calcium imagingFrontiers in neuroscience · 2023Review
- Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles.Developmental neurobiology · 2022Article
- Go with the FLOW: visualizing spatiotemporal dynamics in optical widefield calcium imaging.Journal of the Royal Society, Interface · 2021Article
- The Emergence of Network Activity Patterns in the Somatosensory Cortex - An Early Window to Autism Spectrum Disorders.Neuroscience · 2021Review
- Spontaneous synchronous network activity in the neonatal development of mPFC in mice.Developmental neurobiology · 2021Article
- Micro Three-Dimensional Neuronal Cultures Generate Developing Cortex-Like Activity Patterns.Frontiers in neuroscience · 2020Article
- GABA and Gap Junctions in the Development of Synchronized Activity in Human Pluripotent Stem Cell-Derived Neural Networks.Frontiers in cellular neuroscience · 2018Article
- Article
- Plasticity of neonatal neuronal networks in very premature infants: Source localization of temporal theta activity, the first endogenous neural biomarker, in temporoparietal areas.Human brain mapping · 2017Article
- Article
- Neuronal activity controls the development of interneurons in the somatosensory cortex.Frontiers in biology · 2016Article
- Spindle Activity Orchestrates Plasticity during Development and Sleep.Neural plasticity · 2016Review
- Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions.Frontiers in neural circuits · 2016Review
- GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo.Nature communications · 2015Article
- Glutamatergic system controls synchronization of spontaneous neuronal activity in the murine neonatal entorhinal cortex.Pflugers Archiv : European journal of physiology · 2015Article
- Relationship between individual neuron and network spontaneous activity in developing mouse cortex.Journal of neurophysiology · 2014Article
- Intrinsic neuronal properties switch the mode of information transmission in networks.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Waves of spontaneous electrical activity propagate across many regions of the central nervous system during specific stages of early development. The patterns of wave propagation are critical in the activation of many activity-dependent developmental programs. It is not known how the mechanisms that initiate and propagate spontaneous waves operate during periods in which major changes in neuronal structure and function are taking place. We have recently reported that spontaneous waves of activity propagate across the neonatal mouse cerebral cortex and that these waves are initiated at pacemaker sites in the septal nucleus and ventral cortex. Here we show that spontaneous waves occur between embryonic day 18 (E18) and postnatal day 12 (P12), and that during that period they undergo major changes in transmitter dependence and propagation patterns. At early stages, spontaneous waves are largely GABA dependent and are mostly confined to the septum and ventral cortex. As development proceeds, wave initiation depends increasingly on AMPA-type glutamate receptors, and an ever increasing fraction of waves propagate into the dorsal cortex. The initiation sites and restricted propagation of waves at early stages are highly correlated with the position of GABAergic neurons in the cortex. The later switch to a glutamate-based mechanism allows propagation of waves into the dorsal cortex, and appears to be a compensatory mechanism that ensures continued wave generation even as GABA transmission becomes inhibitory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.