ArticleThe Journal of physiology2011
Activation of silent and weak synapses by cAMP-dependent protein kinase in cultured cerebellar granule neurons.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation.Frontiers in synaptic neuroscience · 2026Review
- Green fluorescent cAMP indicator of high speed and specificity suitable for neuronal live-cell imaging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation.Nature communications · 2021Article
- Synaptic vesicle generation from activity-dependent bulk endosomes requires a dephosphorylation-dependent dynamin-syndapin interaction.Journal of neurochemistry · 2019Article
- Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.Cellular and molecular neurobiology · 2019Article
- Article
- Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.Scientific reports · 2017Article
- Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum.Nature neuroscience · 2016Article
- Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments.Molecular neurobiology · 2015Article
- The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Biochemical pharmacology · 2015Review
- Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.Neuropharmacology · 2015Article
- Regulation of density of functional presynaptic terminals by local energy supply.Molecular brain · 2015Article
- Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum.Neural plasticity · 2015Article
- Article
- Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells.PloS one · 2014Article
- 4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.PloS one · 2014Article
- Synaptic vesicle generation from activity-dependent bulk endosomes requires calcium and calcineurin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Control of synaptic vesicle endocytosis by an extracellular signalling molecule.Nature communications · 2013Article
- Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Presynaptically silent synapses: dormancy and awakening of presynaptic vesicle release.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Presynaptic long term potentiation of synaptic transmission activates silent synapses and potentiates existing active synapses. We sought to visualise these two processes by studying the cAMP-dependent protein kinase (PKA) potentiation of presynaptic vesicle cycling in cultured cerebellar granule neurons.Using FM dyes to label the pool of recycling synaptic vesicles,we found that trains of electrical stimulation which do not potentiate already active synapses are sufficient to rapidly activate a discrete population comprising silent and very low activity synapses. Silent synapse activation required PKA activity and conversely, active synapses could be silenced by PKA inhibition. Surprisingly, the recycling pool of synaptic vesicles in recently activated synapses was larger than in already active synapses and equivalent to synapses treated with forskolin. Imaging of synaptic vesicle cycling and cytosolic Ca(2+) in individual nerve terminals confirmed that silent synapses have evoked Ca(2+) transients comparable to those of active synapses. Furthermore, across populations of active synapses, changes in Ca(2+) influx did not correlate with changes in the size of the pool of recycling synaptic vesicles. Finally, we found that stimulation of synapsin phosphorylation, but not RIM1α, by PKA was frequency dependent and long lasting. These data are consistent with the idea that PKA regulates synaptic vesicle recycling downstream of Ca(2+) influx and that this pathway is highly active in recently activated synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.