ArticleThe Journal of physiology2011
Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice.bioRxiv : the preprint server for biology · 2024Article
- The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions.International journal of molecular sciences · 2021Review
- Parallel processing of afferent olfactory sensory information.The Journal of physiology · 2016Article
- Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex.Nature communications · 2016Article
- A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Frontiers in cellular neuroscience · 2016Review
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor.PloS one · 2015Article
- Article
- Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel.The Journal of physiology · 2013Article
- Distinct modes of dopamine and GABA release in a dual transmitter neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A new human DSG2-transgenic mouse model for studying the tropism and pathology of human adenoviruses.Journal of virology · 2012Article
- Small-scale module of the rat granular retrosplenial cortex: an example of the minicolumn-like structure of the cerebral cortex.Frontiers in neuroanatomy · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Odours generate activity in olfactory receptor neurons, whose axons contact the dendritic tufts of mitral cells within olfactory bulb glomeruli. These axodendritic synapses are anatomically separated from dendrodendritic synapses within each glomerulus. Mitral cells within a glomerulus show highly synchronized activity as assessed with whole-cell recording from pairs of mitral cells. We examined glomerular activity in mice lacking the olfactory cell adhesion molecule (OCAM). Glomeruli in mice lacking OCAM show a redistribution of synaptic subcompartments, but the total area occupied by axonal inputs was similar to wild-type mice. Stimulation of olfactory nerve bundles showed that excitatory synaptic input to mitral cells as well as dendrodendritic inhibition was unaffected in the knockout. However, correlated spiking in mitral cells was significantly reduced, as was electrical coupling between apical dendrites. To analyse slow network dynamics we induced slow oscillations with a glutamate uptake blocker. Evoked and spontaneous slow oscillations in mitral cells and external tufted cells were broader and had multiple peaks in OCAM knockout mice, indicating that synchrony of slow glomerular activity was also reduced. To assess the degree of shared activity between mitral cells under physiological conditions, we analysed spontaneous sub-threshold voltage oscillations using coherence analysis. Coherent activity was markedly reduced in cells from OCAM knockout mice across a broad range of frequencies consistent with a decrease in tightly time-locked activity. We suggest that synchronous activity within each glomerulus is dependent on segregation of synaptic subcompartments.
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