ArticleBritish journal of pharmacology2011
Effects of inhibitors of hydrogen sulphide synthesis on rat colonic motility.
Article in British journal of pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Pharmacological inhibition of hydrogen sulfide production mitigates constipation in a type 1 diabetes mouse model.Scientific reports · 2026Article
- Role of hydrogen sulfide in health and disease.MedComm · 2024Review
- Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.Microorganisms · 2024Article
- Effects of hydrogen sulfide on relaxation responses in the lower esophageal sphincter in rabbits: the potential role of potassium channels.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications.Asian journal of pharmaceutical sciences · 2024Review
- CSE/HFrontiers in immunology · 2022Article
- Mechanisms Associated to Nitroxyl (HNO)-Induced Relaxation in the Intestinal Smooth Muscle.Frontiers in physiology · 2020Article
- Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide.Pharmacology research & perspectives · 2017Article
- International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of HPharmacological reviews · 2017Review
- Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Hydrogen sulphide as a signalling molecule regulating physiopathological processes in gastrointestinal motility.British journal of pharmacology · 2017Review
- Gasotransmitter Heterocellular Signaling.Antioxidants & redox signaling · 2017Article
- Redefining the role of peripheral LPS as a neuroinflammatory agent and evaluating the role of hydrogen sulphide through metformin intervention.Inflammopharmacology · 2016Article
- Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract.Microorganisms · 2015Review
- H2S, a novel gasotransmitter, involves in gastric accommodation.Scientific reports · 2015Article
- Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice.World journal of gastroenterology · 2015Article
- Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.American journal of physiology. Cell physiology · 2015Article
- Article
- Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract.Gastroenterology · 2014Review
- Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration.Cell stem cell · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe role of hydrogen sulphide (H₂S) as a putative endogenous signalling molecule in the gastrointestinal tract has not yet been established. We investigated the effect of D,L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase (CSE), amino-oxyacetic acid (AOAA) and hydroxylamine (HA), inhibitors of cystathionine β-synthase (CBS) on rat colonic motility. EXPERIMENTAL APPROACH: Immunohistochemistry, H₂S production, microelectrode and organ bath recordings were performed on rat colonic samples without mucosa and submucosa to investigate the role of endogenous H₂S in motility. KEY
resultsCSE and CBS were immunolocalized in the colon. H₂S was endogenously produced (15.6 ± 0.7 nmol·min⁻¹·g⁻¹ tissue) and its production was strongly inhibited by PAG (2 mM) and AOAA (2 mM). PAG (2 mM) caused smooth muscle depolarization and increased spontaneous motility. The effect was still recorded after incubation with tetrodotoxin (TTX, 1 µM) or N(ω) -nitro-L-arginine (L-NNA, 1 mM). AOAA (2 mM) caused a transient (10 min) increase in motility. In contrast, HA (10 µM) caused a 'nitric oxide-like effect', smooth muscle hyperpolarization and relaxation, which were antagonized by 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one (ODQ, 10 µM). Neither spontaneous nor induced inhibitory junction potentials were modified by AOAA or PAG. CONCLUSIONS AND IMPLICATIONS: We demonstrated that H₂S is endogenously produced in the rat colon. PAG and AOAA effectively blocked H₂S production. Our data suggest that enzymatic production of H₂S regulates colonic motility and therefore H₂S ight be a third gaseous inhibitory signalling molecule in the gastrointestinal tract. However, possible non-specific effects of the inhibitors should be considered.
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