ReviewDialogues in clinical neuroscience2011
Major depressive disorder is a risk factor for low bone mass, central obesity, and other medical conditions.
Review in Dialogues in clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Depression, antidepressants, and bone health in older adults: a systematic review.Journal of the American Geriatrics Society · 2014Pooled it
- Trial
- Association of severe depression with bone mineral content: a mediation analysis in PERSIAN cohort study.BMC public health · 2026Article
- Combining body mass index with waist circumference to assess coronary microvascular function in patients with non-obstructive coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The relationship between osteoporosis and depression.Scientific reports · 2022Article
- Article
- Crosstalk between Bone and Nerves within Bone.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Article
- Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.International journal of molecular sciences · 2020Review
- Risk of hip fractures in patients with depressive disorders: A nationwide, population-based, retrospective, cohort study.PloS one · 2018Article
- Risk of Vertebral Fracture in Patients Diagnosed with a Depressive Disorder: A Nationwide Population-Based Cohort Study.Clinics (Sao Paulo, Brazil) · 2017Article
- Stress and Alterations in Bones: An Interdisciplinary Perspective.Frontiers in endocrinology · 2017Review
- Article
- In psychiatrically healthy individuals, overweight women but not men have lower tryptophan levels.Pteridines · 2015Article
- Article
- Depressive symptoms are associated with lower bone mineral density in young adults with high job strain. The Cardiovascular Risk in Young Finns Study.International journal of behavioral medicine · 2014Article
- Controversies about a common etiology for eating and mood disorders.Frontiers in psychology · 2014Review
- Differential effects of chronic social stress and fluoxetine on meal patterns in mice.Appetite · 2013Article
- The epidemiology of depression across cultures.Annual review of public health · 2013Review
- Rate of weight gain and cardiometabolic abnormalities in children and adolescents.The Journal of pediatrics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD) is one of the most common psychiatric illnesses in the adult population. It is often associated with an increased risk of cardiovascular disease. Osteoporosis is also a major public health threat. Multiple studies have reported an association between depression and low bone mineral density, but a causal link between these two conditions is disputed. Here the most important findings of the POWER (Premenopausal, Osteoporosis Women, Alendronate, Depression) Study, a large prospective study of bone turnover in premenopausal women with major depression, are summarized. The endocrine and immune alterations secondary to depression that might affect bone mass, and the possible role of poor lifestyle in the etiology of osteoporosis in subjects with depression, are also reviewed, as is the potential effect of antidepressants on bone loss. It is proposed that depression induces bone loss and osteoporotic fractures, primarily via specific immune and endocrine mechanisms, with poor lifestyle habits as potential contributory factors.
Indexed as
Identifiers
21485748PMC3181971W151821485What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.