ArticleDialogues in clinical neuroscience2011
Inflammation in depression: is adiposity a cause?
Article in Dialogues in clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Maternal Dietary Patterns and Risk of Postpartum Depression: A Systematic Review.Maternal and child health journal · 2023Pooled it
- Psychiatric Safety of Tirzepatide in People With Obesity and No Known Major Psychopathology: A Post Hoc Analysis of SURMOUNT.Obesity (Silver Spring, Md.) · 2026Trial
- Evaluation of antenatal risk factors for postpartum depression: a secondary cohort analysis of the cluster-randomised GeliS trial.BMC medicine · 2020Trial
- The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging.Nutrients · 2018Trial
- Dysregulation of the TLR4/MyD88/NF-κB Signaling Pathway and Pro-Inflammatory Cytokines in First-Episode Major Depressive Disorder: A Cross-Sectional Case-Control Study.Immunity, inflammation and disease · 2026Article
- Article
- Dual-target mechanisms of olanzapine in bipolar disorder: a network pharmacology and molecular docking study revealing phase-specific regulation of longevity and PI3K-Akt pathways.BMC psychiatry · 2025Article
- Phytotherapy and the Role of Bioactive Compounds in Modulating Mechanisms of Overweight and Obesity Comorbid with Depressive Symptoms-A Scoping Review of Mechanisms of Action.Molecules (Basel, Switzerland) · 2025Article
- Elucidating neural molecular mechanisms underlying metabolic disorders-induced neuropsychiatric disorders in mice on prolonged high fructose diet.Metabolic brain disease · 2025Article
- Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Relationship Between Obesity and Depression Considering the Inflammatory Theory.International journal of molecular sciences · 2025Review
- Bidirectional Relationship Between Nutrition and Mental Health and Its Impact on the Health of Canadian Immigrants: An Integrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review.Biomolecules · 2025Review
- Weight-adjusted waist circumference index and chronic diseases as predictors of depression risk in U.S. adults: a cross-sectional study with mediation analysis.Frontiers in nutrition · 2025Article
- The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering.Frontiers in cellular and infection microbiology · 2025Article
- Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology.Psychological medicine · 2024Article
- Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder.Translational psychiatry · 2024Article
- Causal links between sedentary behavior, physical activity, and psychiatric disorders: a Mendelian randomization study.Annals of general psychiatry · 2024Article
- Correlating plasma protein profiles with symptomatology and treatment response in acute phase and early remission of major depressive disorder.Frontiers in psychiatry · 2024Article
- The relationship between BMI and depression: a cross-sectional study.Frontiers in psychiatry · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mounting evidence indicates that inflammation may play a significant role in the development of depression. Patients with depression exhibit increased inflammatory markers, and administration of cytokines and other inflammatory stimuli can induce depressive symptoms. Mechanisms by which cytokines access the brain and influence neurotransmitter systems relevant to depression have also been described, as have preliminary findings indicating that antagonizing inflammatory pathways may improve depressive symptoms. One primary source of inflammation in depression appears to be adiposity. Adipose tissue is a rich source of inflammatory factors including adipokines, chemokines, and cytokines, and a bidirectional relationship between adiposity and depression has been revealed. Adiposity is associated with the development of depression, and depression is associated with adiposity, reflecting a potentional vicious cycle between these two conditions which appears to center around inflammation. Treatments targeting this vicious cycle may be especially relevant for the treatment and prevention of depression as well as its multiple comorbid disorders such as cardiovascular disease, diabetes, and cancer, all of which have also been associated with both depression and inflammation.
Indexed as
Identifiers
21485745PMC3181969W1928617315What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.