Evidence map›Paper›PMID 21484943›Full record

ReviewMicroscopy research and technique2011

The application of nanoparticles in gene therapy and magnetic resonance imaging.

Fernando Herranz, Elena Almarza, Ignacio Rodríguez, Beatriz Salinas, Yamilka Rosell, Manuel Desco, Jeff W Bulte, Jesús Ruiz-Cabello

Abstract readReview
In one paragraph

Review in Microscopy research and technique, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Superparamagnetic Nanoparticles for Atherosclerosis Imaging.Nanomaterials (Basel, Switzerland) · 2014
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fernando HerranzFacultad de Farmacia, Departamento de Química Física II, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Universidad Complutense de Madrid, Madrid, Spain.
Elena Almarza
Ignacio Rodríguez
Beatriz Salinas
Yamilka Rosell
Manuel Desco
Jeff W Bulte
Jesús Ruiz-Cabello

Funding

ValidationU54CA151838 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANES, JUSTIN S. · 2010 to 2014
$11.9M
MR Tracking of Magnetically Labeled Stem Cells in CNSR01NS045062 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2003 to 2013
$4.4M
Developing MPI for Non-Invasive and Quantitative Imaging of Stem CellsR01DA026299 · NIDA · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2008 to 2011
$1.3M
NCI NIH HHS U54 CA151838NIDA NIH HHS R01 DA026299NINDS NIH HHS R01 NS045062
6 · The paper itself

Abstract

The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application.

Indexed as

AnimalsDrug Delivery SystemsGenetic TherapyGenetic VectorsGene Transfer TechniquesHumansMagnetic Resonance ImagingMicroscopy, Electron, TransmissionNanoconjugatesRatsNanoconjugates

Identifiers

PMID21484943
PMCPMC3422774

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.