ArticleInternational journal of cancer2012
Indocyanine green enhanced near-infrared laser treatment of murine mammary carcinoma.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
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- Feasibility of Anti-CEA Dye Conjugate for Cancer-Specific Imaging in Gastric Cancer Cell Lines and Mouse Xenograft Models.Cancers · 2025Article
- A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy.Biomaterials advances · 2025Article
- Photothermal treatment-based heat stress regulates function of myeloid-derived suppressor cells.Scientific reports · 2024Article
- Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms ofBioengineering (Basel, Switzerland) · 2024Article
- Translational screening platform to evaluate chemotherapy in combination with focal therapy for retinoblastoma.Cancer science · 2023Article
- Antibacterial Efficacy of Dual-dye and Dual Laser Photodynamic Therapy on Oral Biofilms ofInternational journal of clinical pediatric dentistry · 2023Article
- Effect of Solubilizing Group on the Antibacterial Activity of Heptamethine Cyanine Photosensitizers.Pharmaceutics · 2023Article
- Potential of Cyanine Derived Dyes in Photodynamic Therapy.Pharmaceutics · 2021Review
- Antimicrobial laser-activated sealants for combating surgical site infections.Biomaterials science · 2021Article
- Enhancing the Stability and Photothermal Conversion Efficiency of ICG by Pillar[5]arene-Based Host-Guest Interaction.Frontiers in chemistry · 2021Article
- Novel near-infrared fluorescent probe for live cell imaging.Experimental and therapeutic medicine · 2020Article
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- Recent advances in photodynamic therapy for cancer and infectious diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Article
- Preparation of photothermal palmitic acid/cholesterol liposomes.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Leveraging Engineering of Indocyanine Green-Encapsulated Polymeric Nanocomposites for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2018Review
- Innovative treatment for hepatocellular carcinoma (HCC).Translational gastroenterology and hepatology · 2018Review
- Near-infrared photothermal/photodynamic therapy with indocyanine green induces apoptosis of hepatocellular carcinoma cells through oxidative stress.Scientific reports · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
It is well accepted that near-infrared (NIR) lasers are appropriate to ablate benign lesions and induce irreversible thermal injury in deeply seated blood vessels. At this wavelength, the laser light penetrates deep (3-5 mm) into the skin. However, many researchers have reported noticeable pain, extending from mild to severe, during and immediately after NIR laser treatment. Intravenous administration of an exogenous chromophore [indocyanine green (ICG), dye] can effectively convert NIR laser light into heat. In this approach, the presence of ICG has shown to enhance thermal injury of blood vessels in the treatment of healthy tissues. However, the effectiveness of thermal injury on the regression of cutaneous carcinomas during ICG/NIR laser therapy has not been assessed. The purpose of our study was to evaluate the potential benefit of using ICG/NIR laser therapy to regress superficial carcinoma with thermal injury. Two groups of A/J mice with subcutaneous mammary adenocarcinoma tumors (7-9 mm) were irradiated with a 808-nm NIR laser preceded by tail vein injection of ICG dye or sterile saline. Histological evaluation of the subcutaneous tissue revealed minor thermal damage and necrosis in the laser/saline group and substantial damage (up to 100% necrosis) in the laser/ICG group. The laser/ICG-treated group showed a steady reduction in tumor volume compared to the laser/saline group: 48% by day 5 (p = 0.045) and 69-70% by days 8, 9 and 10 (p values 0.0005 or less). The vascular-targeted ICG-NIR laser therapy appears to have potential for treating superficial tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.