Trial reportLasers in medical science2012
Photodynamic inactivation of microorganisms present on complete dentures. A clinical investigation. Photodynamic disinfection of complete dentures.
Trial report in Lasers in medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta-analysis.Clinical and experimental dental research · 2021Pooled it
- Strategies for Preventing and Treating Oral Mucosal Infections Associated with Removable Dentures: A Scoping Review.Antibiotics (Basel, Switzerland) · 2024Article
- Oral Health-related Quality of Life Among Denture Stomatitis Patients with Implant Overdenture Treated with Photodynamic Therapy.Oral health & preventive dentistry · 2024Article
- Effectiveness of 405-nm blue LED light for degradation of Candida biofilms formed on PMMA denture base resin.Lasers in medical science · 2019Article
- Photodynamic inactivation of a multispecies biofilm using curcumin and LED light.Lasers in medical science · 2016Article
- Different Photoresponses of Microorganisms: From Bioinhibition to Biostimulation.Current microbiology · 2016Article
- An In Vitro Comparison of Antimicrobial Effects of Curcumin-Based Photodynamic Therapy and Chlorhexidine, on Aggregatibacter actinomycetemcomitans.Journal of lasers in medical sciences · 2016Article
- Susceptibility of multispecies biofilm to photodynamic therapy using Photodithazine®.Lasers in medical science · 2015Article
- Comparative antifungal efficacy of light-activated disinfection and octenidine hydrochloride with contemporary endodontic irrigants.Lasers in medical science · 2015Article
- Inactivation of Aggregatibacter actinomycetemcomitans by two different modalities of photodynamic therapy using Toluidine blue O or Radachlorin as photosensitizers: an in vitro study.Lasers in medical science · 2015Article
- Safety assessment of oral photodynamic therapy in rats.Lasers in medical science · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the effectiveness of photodynamic therapy (PDT) for the disinfection of complete dentures. Biofilm samples were collected from dentures of 60 denture users who were randomly divided into four experimental groups (n = 15 each): subjects whose maxillary dentures were sprayed with 50 and 100 mg/l of Photogem® suspension (groups P50S and P100S) and patients whose maxillary dentures were treated with 50 and 100 mg/l of Photogem® gel (groups P50G and P100G). Dentures with photosensitizers were left in the dark for 30 min (pre-irradiation time) and then irradiated with blue LED light at 37.5 J/cm(2) (26 min). Denture samples were taken with sterile cotton swab before (left side surfaces) and after (right side surfaces) PDT. All microbial material was diluted and plated on selective media for Candida spp., Staphylococcus mutans spp., streptococci and a non-selective media. After incubation (48 h/37°C), the number of colony-forming units (cfu/ml) was counted. Microorganisms grown on selective media were identified using biochemical methods before and after PDT. The data were submitted to McNemar and Kruskal-Wallis tests (α = 0.05). No growth after PDT was observed in 60, 53, 47, and 40% of dentures from P100G, P50G, P100S, and P50S groups, respectively. When evidence of microorganisms' growth was observed, PDT regimens eliminated over 90% of microorganisms on dentures. This clinical study showed that PDT was effective for disinfecting dentures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.