ArticleCurrent genetics2011
Characterization of mitochondrial mRNAs in codfish reveals unique features compared to mammals.
Article in Current genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- First report of the complete mitochondrial genome ofHeliyon · 2024Article
- The mitochondrial transcriptome of the anglerfish Lophius piscatorius.BMC research notes · 2019Article
- Variation and evolution of polyadenylation profiles in sauropsid mitochondrial mRNAs as deduced from the high-throughput RNA sequencing.BMC genomics · 2017Article
- Mitochondrial RNA processing in absence of tRNA punctuations in octocorals.BMC molecular biology · 2017Article
- Complete mitochondrial genome of darkfin hindMitochondrial DNA. Part B, Resources · 2016Article
- Mitochondrial DNA Sequence and Lack of Response to Anoxia in the Annual Killifish Austrofundulus limnaeus.Frontiers in physiology · 2016Article
- An evolutionary preserved intergenic spacer in gadiform mitogenomes generates a long noncoding RNA.BMC evolutionary biology · 2014Article
- Article
- Complete mitochondrial genomes of two cockroaches, Blattella germanica and Periplaneta americana, and the phylogenetic position of termites.Current genetics · 2012Article
- LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.The EMBO journal · 2012Article
- Termination of protein synthesis in mammalian mitochondria.The Journal of biological chemistry · 2011Review
- The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.PLoS genetics · 2011Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression and processing of mitochondrial gene transcripts are fundamental to mitochondrial function, but information from early vertebrates like teleost fishes is essentially lacking. We have analyzed mitogenome sequences of ten codfishes (family Gadidae), and provide complete sequences from three new species (Saithe, Pollack and Blue whiting). Characterization of the mitochondrial mRNAs in Saithe and Atlantic cod identified a set of ten poly(A) transcripts, and six UAA stop codons are generated by posttranscriptional polyadenylation. Structural assessment of poly(A) sites is consistent with an RNaseP cleavage activity 5' of tRNA acceptor-like stems. COI, ND5 and ND6 mRNAs were found to harbor 3' UTRs with antisense potential extending into neighboring gene regions. While the 3' UTR of COI mRNA is complementary to the tRNA(Ser UCN) and highly similar to that detected in human mitochondria, the ND5 and ND6 3' UTRs appear more heterogenic. Deep sequencing confirms expression of all mitochondrial mRNAs and rRNAs, and provides information about the precise 5' ends in mature transcripts. Our study supports an overall evolutionary conservation in mitochondrial RNA processing events among vertebrates, but reveals some unique 5' and 3' end characteristics in codfish mRNAs with implications to antisense regulation of gene expression.
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