ArticleJournal of neurodevelopmental disorders2011
Glutathione pathway gene variation and risk of autism spectrum disorders.
Article in Journal of neurodevelopmental disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
- A randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disorders.BMC psychiatry · 2013Trial
- Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Early-life oxidative stress programs persistent NFκB activation and neuroinflammation in autism spectrum disorder.Frontiers in immunology · 2026Article
- Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis.International journal of molecular sciences · 2025Review
- Review
- Article
- DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Parental occupational exposure to solvents and autism spectrum disorder: An exploratory look at gene-environment interactions.Environmental research · 2023Article
- How Is CYP17A1 Activity Altered in Autism? A Pilot Study to Identify Potential Pharmacological Targets.Life (Basel, Switzerland) · 2022Article
- A Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment.Antioxidants (Basel, Switzerland) · 2022Article
- Utilizing Genomically Targeted Molecular Data to Improve Patient-Specific Outcomes in Autism Spectrum Disorder.International journal of molecular sciences · 2022Article
- Construction of an immune-related ceRNA network to screen for potential diagnostic markers for autism spectrum disorder.Frontiers in genetics · 2022Article
- Oxidative Stress in Autism Spectrum Disorder-Current Progress of Mechanisms and Biomarkers.Frontiers in psychiatry · 2022Review
- Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xJournal of neuroscience research · 2021Article
- Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes.Journal of personalized medicine · 2021Article
- Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder.Oxidative medicine and cellular longevity · 2021Article
- Glutathione S-Transferase Polymorphisms and Clinical Characteristics in Autism Spectrum Disorders.Frontiers in psychiatry · 2021Article
- Oxidative Stress in Autism Spectrum Disorder.Molecular neurobiology · 2020Review
- Postnatal Acetaminophen and Potential Risk of Autism Spectrum Disorder among Males.Behavioral sciences (Basel, Switzerland) · 2020Article
- Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.Antioxidants & redox signaling · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Despite evidence that autism is highly heritable with estimates of 15 or more genes involved, few studies have directly examined associations of multiple gene interactions. Since inability to effectively combat oxidative stress has been suggested as a mechanism of autism, we examined genetic variation 42 genes (308 single-nucleotide polymorphisms (SNPs)) related to glutathione, the most important antioxidant in the brain, for both marginal association and multi-gene interaction among 318 case-parent trios from The Autism Genetic Resource Exchange. Models of multi-SNP interactions were estimated using the trio Logic Regression method. A three-SNP joint effect was observed for genotype combinations of SNPs in glutaredoxin, glutaredoxin 3 (GLRX3), and cystathione gamma lyase (CTH); OR = 3.78, 95% CI: 2.36, 6.04. Marginal associations were observed for four genes including two involved in the three-way interaction: CTH, alcohol dehydrogenase 5, gamma-glutamylcysteine synthetase, catalytic subunit and GLRX3. These results suggest that variation in genes involved in counterbalancing oxidative stress may contribute to autism, though replication is necessary.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.